{{Rsnum
|rsid=10929302
|Gene=UGT1A10
|Chromosome=2
|position=233757136
|Orientation=plus
|GMAF=0.2617
|Gene_s=UGT1A3,UGT1A4,UGT1A5,UGT1A6,UGT1A7,UGT1A8,UGT1A9,UGT1A10
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}Clinically relevant [[UGT1A10]] variant.

{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 6.2 | 41.5 | 52.3
| HCB | 0.0 | 17.8 | 82.2
| JPT | 0.0 | 18.2 | 81.8
| YRI | 17.5 | 36.5 | 46.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 17.8 | 82.2
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs10929302
|Name_s=UGT1A1*93;UGT1A1:-3156G>A
|Gene_s=UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
|Feature=Intron, Intron, Intron, Intron, Intron, Intron, Intron, Intron, NA
|Evidence=Web Resource:http://www.pharmgkb.org/search/annotatedGene/ugt1a1/variant.jsp
|Annotation=*93 is a common variant of UGT1A1 in Caucasian and African-American populations. It is located in the Phenobarbital Response Enhancer Module (an upstream regulatory sequence) and may be important in predicting irinotecan response.
|Drugs=irinotecan
|Drug Classes=
|Diseases=
|Curation Level=In-Depth
|PharmGKB Accession ID=PA162263495
}}

{{PharmGKB
|RSID=rs10929302
|Name_s=UGT1A1:G-3156A
|Gene_s=UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
|Feature=Intron, Intron, Intron, Intron, Intron, Intron, Intron, Intron, NA
|Evidence=PubMed ID:15007088
|Annotation=May be an significant predictor of absolute neurophil count (ANC) after irinotecan treatment, associated with severe neutopenia; -3156G carriers tend to have a lower level of total bilirubin.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145125
}}

{{PMID Auto
|PMID=21309756
|Title=Prevalence of clinically relevant UGT1A alleles and haplotypes in African populations
}}

{{PMID Auto
|PMID=22085899
|Title=UGT1A1 is a major locus influencing bilirubin levels in African Americans
|OA=1
}}

{{PMID Auto
|PMID=18992148
|Title=Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
|OA=1
}}

{{PMID Auto
|PMID=19482841
|Title=Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10929302
|overall_frequency_n=38
|overall_frequency_d=126
|overall_frequency=0.301587
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=34
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}