{{Rsnum
|rsid=10938397
|Chromosome=4
|position=45180510
|Orientation=plus
|GMAF=0.3453
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 34.4 | 41.0 | 24.6
| HCB | 54.8 | 40.5 | 4.8
| JPT | 33.3 | 60.0 | 6.7
| YRI | 62.7 | 32.2 | 5.1
| ASW | 0.0 | 0.0 | 0.0
| CHB | 54.8 | 40.5 | 4.8
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID|19164386|OA=1
}} [[obesity]] and [[type-2 diabetes]]
*[[rs1121980]]
*[[rs7498665]]
*[[rs4752856]]
*[[rs17782313]]
*[[rs2815752]] 
*[[rs10938397]]

{{PMID Auto GWAS
|PMID=19079261
|Trait=Body mass index
|Title=Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
|RiskAllele=G
|Pval=3E-16
|OR=0.19
|ORtxt=[0.13-0.25] kg/m2
|OA=1
}}

{{PharmGKB
|RSID=rs10938397
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19079261; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (Initial Sample Size: 32,387 individuals; Replication Sample Size: 59,092 individuals); (Region: 4p13; Reported Gene(s): GNPDA2; Risk Allele: rs10938397-G); (p-value= 0.0000000000000003).This variant is associated with Body mass index.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740176
}}
{{PMID Auto
|PMID=20061430
|Title=Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population
}}

{{omim
|desc=GLUCOSAMINE-6-PHOSPHATE DEAMINASE 2; GNPDA2
|id=613222
|rsnum=10938397
}}

{{PMID Auto GWAS
|PMID=20935630
|Trait=None
|Title=Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
|RiskAllele=G
|Pval=4E-31
|OR=0.18
|ORtxt=[0.14-0.22] kg/m2 increase
|OA=1
}}
{{PMID Auto
|PMID=20843981
|Title=Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children
|OA=1
}}

{{omim
|id=601665
|rsnum=10938397
}}

{{PMID Auto
|PMID=21796141
|Title=Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
}}

{{PMID Auto
|PMID=21912638
|Title=Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
|OA=1
}}

{{PMID Auto
|PMID=22083549
|Title=Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty
}}

{{PMID|19478790|OA=1
}} The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.

{{PMID|19526209|OA=1
}} Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

{{PMID|19553259|OA=1
}} Common body mass index-associated variants confer risk of extreme obesity.

{{PMID|19910641|OA=1
}} Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus.

{{PMID|19910938}} Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.

{{PMID|20127379|OA=1
}} From monogenic to polygenic obesity: recent advances.

{{PMID|20520848|OA=1
}} Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.

{{PMID|20712903|OA=1
}} Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.

{{PMID|20816195|OA=1
}} Analyses of shared genetic factors between asthma and obesity in children.

{{PMID|20824172|OA=1
}} Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.

{{PMID|21147891}} Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study.

{{PMID|21283731|OA=1
}} FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.

{{PMID|21593506|OA=1
}} Maternal and offspring adiposity-related genetic variants and gestational weight gain.

{{PMID|22179955|OA=1
}} Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10938397
|overall_frequency_n=41
|overall_frequency_d=128
|overall_frequency=0.320312
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=39
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23431394
|Title=Rs4074134 near BDNF gene is associated with type 2 diabetes mellitus in chinese han population independently of body mass index
|OA=1
}}

{{PMID Auto
|PMID=23424664
|Title=Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese children
|OA=1
}}

{{PMID Auto
|PMID=24269186
|Title=An obesity genetic risk score is associated with metabolic syndrome in Chinese children
}}

{{PMID Auto GWAS
  |PMID=23563607
  |Trait=Body mass index
  |Title=Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
  |RiskAllele=G
  |Pval=2E-13
  |OR=1.16
  |ORtxt=[NR]
  |OA=1
}}

{{PMID Auto
|PMID=23471855
|Title=The genetics of childhood obesity and interaction with dietary macronutrients.
|OA=1
}}

{{PMID Auto
|PMID=23533005
|Title=Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder.
}}

{{PMID Auto
|PMID=23588626
|Title=Associations of obesity susceptibility loci with hypertension in Chinese children.
}}

{{PMID Auto
|PMID=25093408
|Title=Obesity-Related Genomic Loci Are Associated with Type 2 Diabetes in a Han Chinese Population
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}