{{Rsnum
|rsid=10941679
|Chromosome=5
|position=44706396
|Orientation=plus
|GMAF=0.3007
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 58.5 | 35.4 | 6.2
| HCB | 36.4 | 40.9 | 22.7
| JPT | 31.1 | 42.2 | 26.7
| YRI | 73.0 | 20.6 | 6.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 36.4 | 40.9 | 22.7
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

[[rs4415084]] and [[rs10941679]] confer risk for estrogen receptor [[breast cancer]] (ER)-positive tumors (OR = 1.27, P = 2.5E-12 for rs10941679) based on a study of 6,145 cases.
{{PMID|18438407}}

{{omim
|desc=BREAST CANCER
|id=114480
|rsnum=10941679
}}

{{PharmGKB
|RSID=rs10941679
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18438407
|Annotation=This variant is associated with risk for estrogen receptor (ER)-positive breast cancer.
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162355812
}}

{{PMID Auto
|PMID=20095854
|Title=Novel Breast Cancer Risk Alleles and Interaction with Ionizing Radiation among U.S. Radiologic Technologists
|OA=1
}}

{{PMID Auto
|PMID=20140701
|Title=Genetic variants on chromosome 5p12 are associated with risk of breast cancer in African American women: the Black Women's Health Study
|OA=1
}}

{{PMID Auto
|PMID=20699374
|Title=Evaluation of Breast Cancer Susceptibility Loci in Chinese Women
|OA=1
}}
{{PMID Auto
|PMID=21118973
|Title=Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction
|OA=1
}}

{{PMID Auto
|PMID=21791674
|Title=Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium
|OA=1
}}

{{PMID Auto
|PMID=21795498
|Title=Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer
}}

{{PMID Auto
|PMID=21795501
|Title=Replication of breast cancer GWAS susceptibility loci in the Women's Health Initiative African American SHARe study
|OA=1
}}

{{PMID Auto
|PMID=22832384
|Title=Genetic variants at 5p12 and risk of breast cancer in Han Chinese
}}

{{PMID|19088016|OA=1
}} Genetic susceptibility loci for breast cancer by estrogen receptor status.

{{PMID|19232126|OA=1
}} Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort.

{{PMID|19330030|OA=1
}} A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).

{{PMID|19567422|OA=1
}} Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.

{{PMID|20146796|OA=1
}} Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.

{{PMID|20484103|OA=1
}} Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women.

{{PMID|22532573|OA=1
}} The role of genetic breast cancer susceptibility variants as prognostic factors.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10941679
|overall_frequency_n=31
|overall_frequency_d=128
|overall_frequency=0.242188
|n_genomes=24
|n_genomes_annotated=0
|n_haplomes=29
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23221726
|Title=Gene-Environment Interactions for Breast Cancer Risk Among Chinese Women: A Report From the Shanghai Breast Cancer Genetics Study
|OA=1
}}

{{PMID Auto
|PMID=23479381
|Title=Breast cancer susceptibility loci in association with age at menarche, age at natural menopause and the reproductive lifespan
}}

{{PMID Auto
|PMID=23704029
|Title=Breast cancer susceptibility loci in association with age at menarche, age at natural menopause and the reproductive lifespan
}}

{{PMID Auto GWAS
  |PMID=23535729
  |Trait=Breast cancer
  |Title=Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
  |RiskAllele=G
  |Pval=2E-37
  |OR=1.13
  |ORtxt=[1.10-1.15]
  |OA=1
}}

{{PMID Auto
|PMID=24528085
|Title=Breast Cancer Association Studies in a Han Chinese Population using 10 European-ancestry-associated Breast Cancer Susceptibility SNPs
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}