{{Rsnum
|rsid=10945919
|Chromosome=6
|position=163765645
|Orientation=plus
|GMAF=0.3462
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 39.8 | 53.1 | 7.1
| HCB | 40.9 | 36.5 | 22.6
| JPT | 47.8 | 43.4 | 8.8
| YRI | 27.2 | 52.4 | 20.4
| ASW | 33.3 | 54.4 | 12.3
| CHB | 40.9 | 36.5 | 22.6
| CHD | 31.2 | 50.5 | 18.3
| GIH | 51.5 | 37.6 | 10.9
| LWK | 26.4 | 50.9 | 22.7
| MEX | 63.8 | 32.8 | 3.4
| MKK | 30.3 | 49.7 | 20.0
| TSI | 39.2 | 41.2 | 19.6
| HapMapRevision=28
}}

{{GWAS Summary
|SNP=rs10945919
|PubMedID=18615156
|Condition=Treatment response to TNF antagonists
|Gene=QKI
|Risk Allele=G
|pValue=3.00E-007
|OR=NA
|95CI=
|OA=1
}}

{{PharmGKB
|RSID=rs10945919
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18615156
|Annotation=This variant is significantly associated with the efficacy of anti-TNF treatment in rheumatoid arthritis (Adjusted P-value: 0.0000003; OR: 4.6 (1.8, 12.3)). The study is a genome-wide association study using the Illumina HapMap300 SNP chip on 89 RA patients prospectively followed after beginning of anti-TNF therapy.
|Drugs=adalimumab; etanercept; infliximab
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA162928822
}}

{{PharmGKB
|RSID=rs10945919
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18615156; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in Rheumatoid Arthritis (Initial Sample Size: 89 cases; Replication Sample Size: NR; Risk Allele: rs10945919-G). This variant is associated with Treatment response to TNF antagonists.
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356478
}}

{{PMID Auto
|PMID=20423481
|Title=Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10945919
|overall_frequency_n=39
|overall_frequency_d=128
|overall_frequency=0.304688
|n_genomes=34
|n_genomes_annotated=0
|n_haplomes=40
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}