{{Rsnum
|rsid=10954213
|Gene=IRF5
|Chromosome=7
|position=128949373
|Orientation=plus
|GMAF=0.4683
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=IRF5
}}{{PMID|18063667}} Systemic [[Lupus]] Erythematosus [[rs10488631]] [[rs2004640]] [[rs10954213]] and [[rs729302]]

{{PMID|18311811}}  Japanese 277 SLE patients and 201 controls. Carriers of the [[rs2004640]]T slightly increased among SLE patients (58.8%) as compared with controls (50.2%). When data from our Japanese population were combined with previously published data from a Korean population, the T allele frequency was found to be significantly increased in SLE patients (P = 8.3 x 10(-5)). While no association was observed for the [[rs10954213]] . significant associations with 3 intron 1 SNPs (-4001, [[rs6953165]], and [[rs41298401]]) were found. The allele frequency of [[rs41298401]]G was significantly decreased in SLE patients (13.0% versus 18.7% in controls; P = 0.017), and the allele frequency of [[rs6953165]]G, which was in absolute linkage disequilibrium with -4001A, was increased in SLE patients (8.8% versus 5.2% in controls; P = 0.034). The Caucasian risk haplotype was not present; instead, a protective haplotype carrying [[rs2004640]]G, [[rs41298401]]G, the deletion in exon 6, and [[rs10954213]]A was identified. SNP [[rs10954213]]

{{PMID|18063667}} A variant located 64 bp upstream of the first untranslated exon (exon 1A), consisting of a 5 bp insertion/deletion CGGGG, may be the causative SNP in this region that is most responsible for increasing SLE risk, the rs# for the CGGGG insertion/deletion is rs77571059.

{{PMID|19479858}} Of 3 [[IRF5]] SNPs studied, the [[rs2280714]](A) SNP - and not this one - had the strongest association (odds ratio 1.42, CI: 1.15-1.75) in Japanese [[SLE]] patients.

{{omim
|id=607218
|desc=INTERFERON REGULATORY FACTOR 5; IRF5
|rsnum=10954213
}}
{{PMID Auto
|PMID=19644876
|Title=Association of STAT4 and BLK, but not BANK1 or IRF5, with primary antiphospholipid syndrome
}}

{{PMID Auto
|PMID=19772658
|Title=Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
|OA=1
}}

{{PMID Auto
|PMID=20691091
|Title=Survival dimensionality reduction (SDR): development and clinical application of an innovative approach to detect epistasis in presence of right-censored data
|OA=1
}}
{{PMID Auto
|PMID=20980283
|Title=The interferon regulatory factor 5 gene confers susceptibility to rheumatoid arthritis and influences its erosive phenotype
}}

{{omim
|id=607218
|rsnum=10954213
|variant=0003
}}

{{omim
|id=612251
|rsnum=10954213
}}

{{PMID Auto
|PMID=21627826
|Title=Cis-regulation of IRF5 expression is unable to fully account for Systemic Lupus Erythematosus association: analysis from multiple experiments with lymphoblastoid cell lines
|OA=1
}}

{{PMID|17189288|OA=1
}} Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation.

{{PMID|17393452}} Structural insertion/deletion variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in systemic lupus erythematosus.

{{PMID|17412832|OA=1
}} Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.

{{PMID|18050197|OA=1
}} Association of an IRF5 gene functional polymorphism with Sjogren's syndrome.

{{PMID|18200047}} IFN-regulatory factor 5 gene variants interact with the class I MHC locus in the Swedish psoriasis population.

{{PMID|18285424|OA=1
}} Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations.

{{PMID|18668568|OA=1
}} Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients.

{{PMID|19567624}} Evidence for genetic association and interaction between the TYK2 and IRF5 genes in systemic lupus erythematosus.

{{PMID|19758313}} Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus.

{{PMID|20080916}} Promoter insertion/deletion in the IRF5 gene is highly associated with susceptibility to systemic lupus erythematosus in distinct populations, but exerts a modest effect on gene expression in peripheral blood mononuclear cells.

{{PMID|20112383|OA=1
}} Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus.

{{PMID|20137629}} [Relationship between polymorphism sites of IRF5, TLR-9 and SLE patients in Shandong Han population].

{{PMID|20231204}} Phenotype-haplotype correlation of IRF5 in systemic sclerosis: role of 2 haplotypes in disease severity.

{{PMID|20479942|OA=1
}} Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.

{{PMID|20639879|OA=1
}} Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.

{{PMID|20652065|OA=1
}} Interferon alpha in systemic lupus erythematosus.

{{PMID|21834935}} A meta-analysis of the association of IRF5 polymorphism with systemic lupus erythematosus.

{{PMID Auto
|PMID=23392701
|Title=Association of rs10954213 polymorphisms and haplotype diversity in interferon regulatory factor 5 with systemic lupus erythematosus: A meta-analysis
}}

{{PMID Auto
|PMID=23288367
|Title=Interferon regulatory factor 5 polymorphisms in sarcoidosis.
}}

{{PMID Auto
|PMID=24116155
|Title=Two functional variants of IRF5 influence the development of macular edema in patients with non-anterior uveitis
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}