{{Rsnum
|rsid=10958409
|Chromosome=8
|position=54414531
|Orientation=plus
|GMAF=0.2163
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 1.8 | 28.3 | 69.9
| HCB | 8.8 | 45.3 | 46.0
| JPT | 7.1 | 39.8 | 53.1
| YRI | 1.4 | 24.5 | 74.1
| ASW | 5.3 | 28.1 | 66.7
| CHB | 8.8 | 45.3 | 46.0
| CHD | 5.5 | 40.4 | 54.1
| GIH | 7.9 | 48.5 | 43.6
| LWK | 0.9 | 25.5 | 73.6
| MEX | 17.5 | 49.1 | 33.3
| MKK | 1.3 | 20.5 | 78.2
| TSI | 2.9 | 26.5 | 70.6
| HapMapRevision=28
}}[http://blog.23andme.com/2008/11/10/snpwatch-study-finds-genetic-links-to-brain-aneurysm-in-both-japanese-and-european-populations/ 23andMe blog] [[aneurysm]]

*[[rs700651]] 	2 	G 	1.18x risk 	1.56x risk
*[[rs10958409]] 8 	A 	1.37x risk 	1.79x risk
*[[rs1333040]] 	9 	T 	1.29x risk 	1.67x risk

{{PMID Auto GWAS
|PMID=18997786
|Trait=Intracranial aneurysm
|Title=Susceptibility loci for intracranial aneurysm in European and Japanese populations
|RiskAllele=A
|Pval=1E-10
|OR=1.36
|ORtxt=[1.24-1.49]
|OA=1
}}

{{omim
|desc=ANEURYSM, INTRACRANIAL BERRY, 10
|id=612587
|rsnum=10958409
}}

{{PharmGKB
|RSID=rs10958409
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18997786; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Susceptibility loci for intracranial aneurysm in European and Japanese populations. (Initial Sample Size: 1,580 European cases, 6,276 European controls; Replication Sample Size: 495 Japanese cases, 676 Japanese controls); (Region: 8q11.23; Reported Gene(s): SOX17; Risk Allele: rs10958409-A); (p-value= 0.0000000001).This variant is associated with Intracranial aneurysm.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740745
}}

{{PMID Auto
|PMID=20190001
|Title=The Relationship Between Smoking and Replicated Sequence Variants on Chromosomes 8 and 9 With Familial Intracranial Aneurysm
|OA=1
}}

{{PMID Auto
|PMID=20395613
|Title=Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10958409
|overall_frequency_n=27
|overall_frequency_d=128
|overall_frequency=0.210938
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=25
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

[[Brain Aneurysm]]

{{PMID Auto
|PMID=22476622
|Title=Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case-control study in China.
}}

{{PMID Auto
|PMID=23733552
|Title=Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}