{{Rsnum
|rsid=10980705
|Gene=LPAR1
|Chromosome=9
|position=111040905
|Orientation=plus
|GMAF=0.1924
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=LPAR1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 54.0 | 38.9 | 7.1
| HCB | 62.5 | 33.1 | 4.4
| JPT | 61.6 | 33.9 | 4.5
| YRI | 99.3 | 0.7 | 0.0
| ASW | 87.7 | 12.3 | 0.0
| CHB | 62.5 | 33.1 | 4.4
| CHD | 58.5 | 37.7 | 3.8
| GIH | 65.7 | 31.3 | 3.0
| LWK | 97.3 | 2.7 | 0.0
| MEX | 41.1 | 44.6 | 14.3
| MKK | 93.6 | 6.4 | 0.0
| TSI | 64.3 | 29.6 | 6.1
| HapMapRevision=28
}}
[[rs10980705]], also known as -2820G/A, is a SNP upstream of the lysophosphatidic acid receptor 1 [[LPAR1]] gene.

In a study of 2 Japanese populations of patients with knee [[osteoarthritis]] (OA), the [[rs10980705]](T) allele (in dbSNP orientation) was associated with increased risk in two Japanese populations, with an odds ratio of 2.3 (CI: 1.6-3.3, p=2.6x10<sup>-5</sup>). The association appears to hold only for the homozygous (T;T) genotype, and the authors state they believe this variant may be the "disease-causing SNP". However, 2% of individuals without knee OA are (T;T) homozygotes, and, over 50% of all patients with knee OA are (C;C) homozygotes.{{PMID|18325907}}

In a study of five collections of samples, and a meta-analysis combining them all, no particularly significant association was seen for [[rs10980705]] with either knee OA or hip OA. These authors conclude it's either a weak effect (and more people need to be studied), or perhaps it's a phenomena more relevant to Asians than to Europeans.{{PMID|18625619}}

{{omim
|desc=LYSOPHOSPHATIDIC ACID RECEPTOR 1; LPAR1
|id=602282
|rsnum=10980705
}}

{{omim
|id=165720
|rsnum=10980705
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}