{{Rsnum
|rsid=10984447
|Gene=DBC1
|Chromosome=9
|position=119222275
|Orientation=plus
|GMAF=0.1657
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=BRINP1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 52.2 | 39.8 | 8.0
| HCB | 83.2 | 16.1 | 0.7
| JPT | 72.6 | 24.8 | 2.7
| YRI | 89.1 | 10.9 | 0.0
| ASW | 80.7 | 17.5 | 1.8
| CHB | 83.2 | 16.1 | 0.7
| CHD | 80.7 | 18.3 | 0.9
| GIH | 60.4 | 34.7 | 5.0
| LWK | 92.7 | 6.4 | 0.9
| MEX | 58.6 | 27.6 | 13.8
| MKK | 94.2 | 5.8 | 0.0
| TSI | 67.6 | 29.4 | 2.9
| HapMapRevision=28
}}
[[rs10984447]] has been reported in a large study to be associated with [[multiple sclerosis]].

The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with this allele is 1.17 (CI 1.09-1.25). {{PMID|17660530}}

{{GWAS Summary
|SNP=rs10984447
|PubMedID=17660530
|Condition=Multiple sclerosis
|Gene=DBC1
|Risk Allele=A
|pValue=8.00E-006
|OR=1.17
|95CI=1.09-1.25
}}

{{PharmGKB
|RSID=rs10984447
|Name_s=
|Gene_s=DBC1
|Feature=
|Evidence=PubMed ID:17660530; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Risk alleles for multiple sclerosis identified by a genomewide study (Initial Sample Size: 931 trios, 2,431 controls; Replication Sample Size: 609 trios, 2,322 cases, 2,987 controls; Risk Allele: rs10984447-A).
|Drugs=
|Drug Classes=
|Diseases=Multiple Sclerosis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356682
}}

{{PharmGKB
|RSID=rs10984447
|Name_s=
|Gene_s=DBC1
|Feature=
|Evidence=PubMed ID:17660530
|Annotation=In a replicated GWAS of U.K. and U.S. case/parent trios, this variant was shown to be associated with multiple sclerosis risk.
|Drugs=
|Drug Classes=
|Diseases=Multiple Sclerosis
|Curation Level=Curated
|PharmGKB Accession ID=PA162356163
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10984447
|overall_frequency_n=23
|overall_frequency_d=128
|overall_frequency=0.179688
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=16
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22492128
|Title=Association of SNPs rs6498169 and rs10984447 with multiple sclerosis in Saudi patients: a model of the usefulness of familial aggregates in identifying genetic linkage in a multifactorial disease.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}