{{Rsnum
|rsid=10993994
|Gene=MSMB
|Chromosome=10
|position=46046326
|Orientation=minus
|GMAF=0.4734
|Gene_s=MSMB,TIMM23B
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 44.2 | 43.4 | 12.4
| HCB | 27.0 | 48.9 | 24.1
| JPT | 38.9 | 46.0 | 15.0
| YRI | 10.9 | 37.4 | 51.7
| ASW | 22.8 | 36.8 | 40.4
| CHB | 27.0 | 48.9 | 24.1
| CHD | 27.5 | 40.4 | 32.1
| GIH | 18.8 | 42.6 | 38.6
| LWK | 8.3 | 33.9 | 57.8
| MEX | 44.8 | 46.6 | 8.6
| MKK | 3.8 | 35.9 | 60.3
| TSI | 33.3 | 49.0 | 17.6
| HapMapRevision=28
}}{{PMID|19153072|OA=1
}} [[rs10993994]] linked to [[prostate cancer]]

[http://cancergenetics.wordpress.com/2008/02/15/prostate-cancer-oldnew-snps-and-decodeprca/ cancer-genetics] these snps influence genetic risk for [[prostate cancer]]
*the [[haplotype]] [[rs6983267]] [[rs1016343]] [[rs4242384]] 
*[[rs7501939]] 
*[[rs1859962]]
*[[rs2660753]]
*[[rs9364554]]
*[[rs6465657]]
*[[rs10993994]]
*[[rs7931342]]
*[[rs2735839]]
*[[rs5945619]]

{{GWAS Summary
|SNP=rs10993994
|PubMedID=18264096
|Condition=Prostate cancer (aggressive)
|Gene=MSMB
|Risk Allele=T
|pValue=7.00E-013
|OR=1.16
|95CI=1.04-1.29
}}
{{PMID Auto
|PMID=19336566
|Title=Replication of the 10q11 and Xp11 Prostate Cancer Risk Variants: Results from a Utah Pedigree-Based Study.
|OA=1
}}
{{PMID Auto
|PMID=19366831
|Title=Analysis of Recently Identified Prostate Cancer Susceptibility Loci in a Population-based Study: Associations with Family History and Clinical Features
|OA=1
}}
{{PMID Auto
|PMID=19383797
|Title=Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility
|OA=1
}}

{{PMID Auto GWAS
|PMID=18264097
|Trait=Prostate cancer
|Title=Multiple newly identified loci associated with prostate cancer susceptibility
|RiskAllele=T
|Pval=8.9999999999999996E-29
|OR=1.25
|ORtxt=[1.17-1.34]
}}

{{omim
|desc=PROSTATE CANCER, HEREDITARY, 13; HPC13
|id=611928
|rsnum=10993994
}}

{{omim
|id=157145
|desc=MICROSEMINOPROTEIN, BETA; MSMB
|rsnum=10993994
}}
{{PMID Auto
|PMID=19644707
|Title=Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer
|OA=1
}}
{{PMID Auto
|PMID=19900942
|Title=Prognostic significance of prostate cancer susceptibility variants on prostate-specific antigen recurrence after radical prostatectomy
}}

{{PharmGKB
|RSID=rs10993994
|Name_s=
|Gene_s=MSMB
|Feature=
|Evidence=PubMed ID:18264096; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Multiple loci identified in a genome-wide association study of prostate cancer (Initial Sample Size: 1,172 cases, 1,157 controls; Replication Sample Size: 3,941 cases, 3,964 controls; Risk Allele: rs10993994-T).
|Drugs=
|Drug Classes=
|Diseases=Prostatic Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356743
}}

{{PMID Auto
|PMID=20333697
|Title=A functional polymorphism in MSMB gene promoter is associated with prostate cancer risk and serum MSMB expression
}}
{{PMID Auto
|PMID=20680031
|Title=Effect of androgen deprivation therapy on the expression of prostate cancer biomarkers MSMB and MSMB-binding protein CRISP3
}}
{{PMID Auto
|PMID=20696662
|Title=Polymorphisms at the Microseminoprotein-{beta} Locus Associated with Physiologic Variation in {beta}-Microseminoprotein and Prostate-Specific Antigen Levels
|OA=1
}}
{{PMID Auto
|PMID=20717903
|Title=Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: The flint men's health study
}}
{{PMID Auto
|PMID=20736317
|Title=A common prostate cancer risk variant 5' of MSMB (microseminoprotein-beta) is a strong predictor of circulating MSP (microseminoprotein) in multiple populations
|OA=1
}}
{{PMID Auto GWAS
|PMID=20676098
|Trait=None
|Title=Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population
|RiskAllele=
|Pval=3E-8
|OR=None
|ORtxt=None
}}
{{PMID Auto
|PMID=20967219
|Title=The rs10993994 Risk Allele for Prostate Cancer Results in Clinically Relevant Changes in Microseminoprotein-Beta Expression in Tissue and Urine
|OA=1
}}

{{PharmGKB
|RSID=rs10993994
|Name_s=
|Gene_s=MSMB
|Feature=
|Evidence=PubMed ID:18264097; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Multiple newly identified loci associated with prostate cancer susceptibility (Initial Sample Size: 1,854 cases, 1,894 controls; Replication Sample Size: 3,268 cases, 3,366 controls; Risk Allele: rs10993994-T).
|Drugs=
|Drug Classes=
|Diseases=Prostatic Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356745
}}
{{PMID Auto
|PMID=21085629
|Title=Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis
|OA=1
}}

{{PMID Auto GWAS
|PMID=21160077
|Trait=None
|Title=Genetic Correction of PSA Values Using Sequence Variants Associated with PSA Levels
|RiskAllele=T
|Pval=7E-13
|OR=9.2000
|ORtxt=[NR] % increase
|OA=1
}}
{{omim
|id=157145
|rsnum=10993994
|variant=0001
}}

{{PMID Auto GWAS
|PMID=21743057
|Trait=None
|Title=Genome-wide association study identifies new prostate cancer susceptibility loci.
|RiskAllele=T
|Pval=0.000005
|OR=1.1800
|ORtxt=[1.10-1.27]
|OA=1
}}

{{PMID Auto
|PMID=22459122
|Title=Interactions Between Genome-wide Significant Genetic Variants and Circulating Concentrations of Insulin-like Growth Factor 1, Sex Hormones, and Binding Proteins in Relation to Prostate Cancer Risk in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
|OA=1
}}

{{PMID Auto
|PMID=22144497
|Title=Assessing the clinical role of genetic markers of early-onset prostate cancer among high-risk men enrolled in prostate cancer early detection
|OA=1
}}

{{PMID Auto
|PMID=22733159
|Title=Analysis of prostate cancer association with four single-nucleotide polymorphisms from genome-wide studies and serum phyto-estrogen concentrations
}}

{{PMID Auto
|PMID=18708398
|Title=Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium.
|OA=1
}}

{{PMID Auto
|PMID=18794092
|Title=Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.
|OA=1
}}

{{PMID Auto
|PMID=18974127
|Title=Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=19104501
|Title=Prostate cancer genomics: towards a new understanding.
|OA=1
}}

{{PMID Auto
|PMID=19318432
|Title=Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.
|OA=1
}}

{{PMID Auto
|PMID=19434657
|Title=Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
|OA=1
}}

{{PMID Auto
|PMID=19549807
|Title=Prostate cancer risk associated loci in African Americans.
|OA=1
}}

{{PMID Auto
|PMID=19639606
|Title=Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
|OA=1
}}

{{PMID Auto
|PMID=19997100
|Title=Mutation analysis of the MSMB gene in familial prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=20039378
|Title=Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
|OA=1
}}

{{PMID Auto
|PMID=20569440
|Title=Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=20690139
|Title=Meta-analysis of genome-wide and replication association studies on prostate cancer.
}}

{{PMID Auto
|PMID=20826827
|Title=Context-dependent effects of genome-wide association study genotypes and macroenvironment on time to biochemical (prostate specific antigen) failure after prostatectomy.
|OA=1
}}

{{PMID Auto
|PMID=21071540
|Title=Validation of genome-wide prostate cancer associations in men of African descent.
|OA=1
}}

{{PMID Auto
|PMID=21343373
|Title=Prostate cancer predisposition loci and risk of metastatic disease and prostate cancer recurrence.
|OA=1
}}

{{PMID Auto
|PMID=21390317
|Title=Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
|OA=1
}}

{{PMID Auto
|PMID=21538423
|Title=Early onset prostate cancer has a significant genetic component.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10993994
|overall_frequency_n=1754
|overall_frequency_d=3234
|overall_frequency=0.542362
|n_genomes=33
|n_genomes_annotated=0
|n_haplomes=43
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22677538
|Title=The prostate cancer risk locus at 10q11 is associated with DNA repair capacity
}}

{{PMID Auto
|PMID=23213189
|Title=Levels of Beta-Microseminoprotein in Blood and Risk of Prostate Cancer in Multiple Populations
|OA=1
}}

{{PMID Auto
|PMID=23405784
|Title=[Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases]
}}

{{PMID Auto GWAS
  |PMID=23269536
  |Trait=Prostate-specific antigen levels
  |Title=Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.
  |RiskAllele=T
  |Pval=5E-17
  |OR=.12
  |ORtxt=[NR] % higher levels
  }}

{{PMID Auto
|PMID=23937305
|Title=Validation of association of genetic variants at 10q with prostate-specific antigen (PSA) levels in men at high risk for prostate cancer
}}

{{PMID Auto GWAS
  |PMID=23555189
  |Trait=PCA3 expression level
  |Title=Genome-wide association study identifies genetic determinants of urine PCA3 levels in men.
  |RiskAllele=T
  |Pval=1E-9
  |OR=1.25
  |ORtxt=[1.18-1.32] unit increase
  |OA=1
}}

{{PMID Auto
|PMID=24411283
|Title=Prostate Cancer (PCa) Risk Variants and Risk of Fatal PCa in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
}}

{{PMID Auto
|PMID=24464504
|Title=MSMB variation and prostate cancer risk: Clues towards a possible fungal etiology
}}

{{PMID Auto
|PMID=22887727
|Title=Investigation of the relationship between prostate cancer and MSMB and NCOA4 genetic variants and protein expression.
|OA=1
}}

{{PMID Auto
|PMID=23246478
|Title=Personalized prostate specific antigen testing using genetic variants may reduce unnecessary prostate biopsies.
|OA=1
}}

{{PMID Auto
|PMID=23608167
|Title=Association of prostate cancer susceptibility variant (MSMB) rs10993994 with risk of spermatogenic failure.
}}

{{PMID Auto
|PMID=24987558
|Title=Promoter Polymorphism (rs12770170, -184C/T) of Microseminoprotein, Beta as a Risk Factor for Benign Prostatic Hyperplasia in Korean Population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}