{{Rsnum
|rsid=10994336
|Gene=ANK3
|Chromosome=10
|position=62179812
|Orientation=plus
|GMAF=0.1318
|Gene_s=ANK3
|Assembly=GRCh37.p5
|GenomeBuild=37.3
|dbSNPBuild=135
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 86.2 | 13.8 | 0.0
| HCB | 66.7 | 26.7 | 6.7
| JPT | 46.5 | 39.5 | 14.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 66.7 | 26.7 | 6.7
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[http://blog.23andme.com/2008/08/18/snpwatch-snps-in-ion-channel-genes-are-associated-with-type-2-diabetes-and-bipolar-disorder/ 23andMe blog] [[rs10994336]] or ([[rs4948418]]) Each T at this SNP increased the odds of developing bipolar disorder by 1.45 times compared to the CC genotype.
{{GWAS Summary
|SNP=rs10994336
|PubMedID=18711365
|Condition=Bipolar disorder
|Gene=ANK3
|Risk Allele=T
|pValue=9.00E-009
|OR=1.45
|95CI=
|OA=1
}}

This is one of the SNPs reported by [[NutraHacker SNPs|NutraHacker]].

{{PMID Auto
|PMID=19416921
|Title=Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry
|OA=1
}}

{{omim
|desc=MAJOR AFFECTIVE DISORDER 1; MAFD1
|id=125480
|rsnum=10994336
}}

{{omim
|desc=MAJOR AFFECTIVE DISORDER 8; MAFD8
|id=612357
|rsnum=10994336
}}

{{PharmGKB
|RSID=rs10994336
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18711365; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder (Initial Sample Size: 1,098 cases, 1,267 controls; Replication Sample Size: 4,387 cases, 6,209 controls; Risk Allele: rs10994336-T). This variant is associated with Bipolar disorder.
|Drugs=
|Drug Classes=
|Diseases=Bipolar Disorder
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356412
}}

{{PMID Auto
|PMID=20636642
|Title=Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression
}}

{{PharmGKB
|RSID=rs10994336
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18711365
|Annotation=A genome-wide association analysis study in 4,387 cases and 6,209 controls identified a strong association of this variant in the ANK3 gene with bipolar disorder.
|Drugs=
|Drug Classes=
|Diseases=Bipolar Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA162355588
}}

{{PMID Auto
|PMID=21676128
|Title=The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males
}}

{{PMID Auto
|PMID=19088739
|Title=Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder.
|OA=1
}}

{{PMID Auto
|PMID=21304963
|Title=The cognitive impact of the ANK3 risk variant for bipolar disorder: initial evidence of selectivity to signal detection during sustained attention.
|OA=1
}}

{{PMID Auto
|PMID=21395576
|Title=No association between bipolar disorder risk polymorphisms in ANK3 and CACNA1C and common migraine.
}}

{{PMID Auto
|PMID=21438140
|Title=Association of ANK3 with bipolar disorder confirmed in East Asia.
}}

{{PMID Auto
|PMID=21767209
|Title=ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.
}}

{{PMID Auto
|PMID=21972176
|Title=Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples.
}}

{{PMID Auto
|PMID=22079454
|Title=Genome-wide supported risk variant for bipolar disorder alters anatomical connectivity in the human brain.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10994336
|overall_frequency_n=12
|overall_frequency_d=128
|overall_frequency=0.09375
|n_genomes=8
|n_genomes_annotated=0
|n_haplomes=10
|n_articles=1
|n_articles_annotated=1
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23109352
|Title=ANK3 as a risk gene for schizophrenia: New data in han Chinese and meta analysis
}}

{{PMID Auto
|PMID=24016415
|Title=Association of a risk allele of ANK3 with cognitive performance and cortical thickness in patients with first-episode psychosis
|OA=1
}}

{{PMID Auto
|PMID=24108394
|Title=Independent Modulation of Engagement and Connectivity of the Facial Network During Affect Processing by CACNA1C and ANK3 Risk Genes for Bipolar Disorder
}}

{{PMID Auto
|PMID=24361380
|Title=Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia
}}

{{PMID Auto
|PMID=22005930
|Title=Genome-wide association study of Alzheimer's disease with psychotic symptoms.
|OA=1
}}

{{PMID Auto
|PMID=22498896
|Title=Bipolar disorder ANK3 risk variant effect on sustained attention is replicated in a large healthy population.
}}

{{PMID Auto
|PMID=23070075
|Title=Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample.
}}

{{PMID Auto
|PMID=24914473
|Title=Genetic association of LMAN2L gene in schizophrenia and bipolar disorder and its interaction with ANK3 gene polymorphism
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}