{{Rsnum
|rsid=10994982
|Gene=ARID5B
|Chromosome=10
|position=63710104
|Orientation=plus
|GMAF=0.4761
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 18.6 | 54.0 | 27.4
| HCB | 24.8 | 48.2 | 27.0
| JPT | 18.8 | 60.7 | 20.5
| YRI | 29.3 | 53.7 | 17.0
| ASW | 26.3 | 50.9 | 22.8
| CHB | 24.8 | 48.2 | 27.0
| CHD | 24.1 | 49.1 | 26.9
| GIH | 57.4 | 35.6 | 6.9
| LWK | 43.6 | 40.0 | 16.4
| MEX | 22.4 | 60.3 | 17.2
| MKK | 29.5 | 49.4 | 21.2
| TSI | 33.3 | 43.1 | 23.5
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs10994982
|Name_s=
|Gene_s=ARID5B
|Feature=Intron
|Evidence=PubMed ID:19684603
|Annotation=This SNP located in intron 3 of the ARID5B gene differed between pediatric acute lymphoblastic leukemia (ALL) and non-ALL groups (rs10994982, P = 5.7 x 10(-9), OR = 1.62) and also distinguished B-hyperdiploid ALL from other subtypes (rs10994982, P = 0.003, OR 1.72). This SNP was in linkage disequilibrium with rs10821936 (r2 = 0.42, P < 1 10-10). The study found found that the same alleles of this ARID5B SNP rs10994982 that were associated with B-hyperdiploid ALL were also associated with greater methotrexate polyglutamate accumulation (P = 0.021).
|Drugs=methotrexate
|Drug Classes=
|Diseases=Precursor Cell Lymphoblastic Leukemia-Lymphoma
|Curation Level=Curated
|PharmGKB Accession ID=PA165106633
}}

{{omim
|id=613065
|rsnum=10994982
}}

{{PMID|20460642|OA=1
}} Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs10994982
|overall_frequency_n=59
|overall_frequency_d=128
|overall_frequency=0.460938
|n_genomes=41
|n_genomes_annotated=0
|n_haplomes=54
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23692655
|Title=ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group
}}

{{PMID Auto
|PMID=24564228
|Title=ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia
|OA=1
}}

{{PMID Auto
|PMID=25124600
|Title=Associations between AT-rich Interactive Domain 5B gene Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: a Meta-analysis
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}