{{Rsnum
|rsid=1113129
|Gene=CYP2C8
|Chromosome=10
|position=96811045
|Orientation=plus
|GMAF=0.3292
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=132
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 4.6 | 27.7 | 67.7
| HCB | 11.1 | 46.7 | 42.2
| JPT | 9.1 | 59.1 | 31.8
| YRI | 30.2 | 39.7 | 30.2
| ASW | 0.0 | 0.0 | 0.0
| CHB | 11.1 | 46.7 | 42.2
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs1113129
|Name_s=rs1113129 G>C; CYP2C8-HapC; Haplotype low act
|Gene_s=CYP2C8
|Feature=
|Evidence=PubMed ID:20212519
|Annotation=Risk or phenotype-associated allele: C. Phenotype: This variant was associated with reduced risk for neurotoxicity with paclitaxel treatment. Study size: 132. Study population/ethnicity: Patients with Neoplasms receiving paclitaxel; Spain. Significance metric(s): HR = 0.59 (0.36-0.94); p = 0.026. Type of association: PK; TOX.
|Drugs=paclitaxel
|Drug Classes=
|Diseases=Drug Toxicity; Neurotoxicity Syndromes
|Curation Level=Curated
|PharmGKB Accession ID=PA165291996
}}

{{PMID|18303964}} Impact of genetic polymorphisms in CYP2C8 and rosiglitazone intake on the urinary excretion of dihydroxyeicosatrienoic acids.

{{PMID|18769365|OA=1
}} Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease.

{{PMID|19761371|OA=1
}} Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1113129
|overall_frequency_n=42
|overall_frequency_d=124
|overall_frequency=0.33871
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=36
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}