{{Rsnum
|rsid=11136000
|Gene=CLU
|Chromosome=8
|position=27607002
|Orientation=plus
|GMAF=0.3848
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CLU
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 40.7 | 48.7 | 10.6
| HCB | 62.8 | 33.6 | 3.6
| JPT | 60.2 | 34.5 | 5.3
| YRI | 14.3 | 55.1 | 30.6
| ASW | 15.8 | 50.9 | 33.3
| CHB | 62.8 | 33.6 | 3.6
| CHD | 55.0 | 38.5 | 6.4
| GIH | 51.5 | 38.6 | 9.9
| LWK | 17.3 | 44.5 | 38.2
| MEX | 48.3 | 32.8 | 19.0
| MKK | 25.0 | 53.2 | 21.8
| TSI | 35.3 | 49.0 | 15.7
| HapMapRevision=28
}}[[rs11136000]] is a SNP associated with the clusterin [[CLU]] gene, which has also been known as the APOJ gene.

A study of over 5,000 [[Alzheimer's disease]] patients (and over 10,000 controls) found a slight protective effect of the (T) allele of this SNP. [[rs11136000]](T) carriers had a slightly decreased risk for [[Alzheimer's disease]], with an odds ratio of 0.84 (CI: 0.8-0.9, p=1.4x10e-9).{{doi|10.1038/ng.440}}

{{PMID|20554627|OA=1
}} The association of this SNP and late-onset [[Alzheimer's disease]] was replicated over a total of another 1829 cases (and 2576 controls). 

{{PMID|21543606|OA=1
}} A MRI study of ~400 young (average age: 23) healthy carriers of [[rs11136000]](C) alleles found a distinct profile of lower white matter integrity in these individuals that may increase their vulnerability to developing Alzheimer's later in life. To put it another way, 50 years before the actual development of Alzheimer's, most of us - after all, the (C) allele is the common one - apparently show some evidence of weakness in myelin, the protective covering around the neuron’s axons in the brain, (slightly) predisposing us to late-onset Alzheimer’s, at least compared to carriers of one or two (T) alleles.

{{PMID Auto GWAS
|PMID=19734902
|Trait=Alzheimer's disease
|Title=Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
|RiskAllele=
|Pval=9E-10
|OR=1.16
|ORtxt=[1.11-1.22]
|OA=1
}}

{{PMID Auto
|PMID=19734903
|Title=Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
}}

{{PMID Auto
|PMID=20697030
|Title=Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes
|OA=1
}}

{{PMID Auto
|PMID=21321396
|Title=Replication of BIN1 Association with Alzheimer's Disease and Evaluation of Genetic Interactions
|OA=1
}}

{{omim
|id=104300
|rsnum=11136000
}}

{{PMID Auto
|PMID=21912625
|Title=An exploratory study on CLU, CR1 and PICALM and Parkinson disease
|OA=1
}}

{{PMID Auto
|PMID=22248099
|Title=Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
|OA=1
}}

{{PMID Auto
|PMID=22122982
|Title=Association of clusterin gene polymorphisms with late-onset Alzheimer's disease
}}

{{PMID Auto
|PMID=22722634
|Title=Novel late-onset Alzheimer disease loci variants associate with brain gene expression.
|OA=1
}}

{{PMID Auto
|PMID=18806885
|Title=Genetic analysis of the clusterin gene in pseudoexfoliation syndrome.
|OA=1
}}

{{PMID Auto
|PMID=20209083
|Title=Genetic variability in CLU and its association with Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=20599866
|Title=Implication of CLU gene polymorphisms in Chinese patients with Alzheimer's disease.
}}

{{PMID Auto
|PMID=20738160
|Title=Association analysis between the rs11136000 single nucleotide polymorphism in clusterin gene, rs3851179 single nucleotide polymorphism in clathrin assembly lymphoid myeloid protein gene and the patients with schizophrenia in the Chinese population.
}}

{{PMID Auto
|PMID=20739100
|Title=Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.
|OA=1
}}

{{PMID Auto
|PMID=21347408
|Title=Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=21358043
|Title=PICALM and CR1 variants are not associated with sporadic Alzheimer's disease in Chinese patients.
}}

{{PMID Auto
|PMID=21379329
|Title=Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
|OA=1
}}

{{PMID Auto
|PMID=21390209
|Title=Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=21391232
|Title=CR1 is associated with amyloid plaque burden and age-related cognitive decline.
|OA=1
}}

{{PMID Auto
|PMID=21397462
|Title=Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene.
}}

{{PMID Auto
|PMID=21422520
|Title=Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration.
}}

{{PMID Auto
|PMID=21726919
|Title=CR1 genotype is associated with entorhinal cortex volume in young healthy adults.
}}

{{PMID Auto
|PMID=22015308
|Title=Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11136000
|overall_frequency_n=67
|overall_frequency_d=128
|overall_frequency=0.523438
|n_genomes=43
|n_genomes_annotated=0
|n_haplomes=62
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22402018
|Title=Implication of common and disease specific variants in CLU, CR1, and PICALM
}}

{{PMID Auto
|PMID=23419238
|Title=Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms
|OA=1
}}

{{PMID Auto
|PMID=23650005
|Title=Lack of association of CR1, PICALM and CLU gene polymorphisms with Alzheimer disease in a Polish population
}}

{{PMID Auto
|PMID=24117116
|Title=Plasma Clusterin Levels and the rs11136000 Genotype in Individuals with Mild Cognitive Impairment and Alzheimer's Disease
}}

{{PMID Auto
|PMID=22005930
|Title=Genome-wide association study of Alzheimer's disease with psychotic symptoms.
|OA=1
}}

{{PMID Auto
|PMID=22795969
|Title=Alzheimer risk variant CLU and brain function during aging.
|OA=1
}}

{{PMID Auto
|PMID=25051234
|Title=Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease
}}

{{PMID Auto
|PMID=25189118
|Title=Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}