{{Rsnum
|rsid=11178997
|Gene=TPH2
|Chromosome=12
|position=71938373
|Orientation=plus
|GMAF=0.1446
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=TPH2
}}[[rs4570625]] and [[rs11178997]] in [[TPH2]]'s regulatory region display preferential transmission

[http://archpsyc.ama-assn.org/cgi/content/full/63/10/1103?ck=nck paper] Association with and [[bipolar disorder]] in a Northern Swedish, Isolated Population. 182 patients and 364 unrelated control individuals. P = .001

{{PMID|17568567}} rs11178997 significantly reduced TPH2 transcriptional activity by 22% and 7% in cell lines might have implications for the development and function of the serotonergic system in the brain.

[http://www.thieme-connect.com/ejournals/abstract/pharmaco/doi/10.1055/s-2007-991720 paper] Carriers of the A-Allele of rs11178997 showed a decreased cortisol and [[ACTH]] stimulation. might be crucial factors for major [[depression]]

[http://hmg.oxfordjournals.org/cgi/reprint/ddm286v1.pdf pdf paper] associated with [[bipolar disorder]]

{{PMID|17905754}} Minor allele yielded odds ratio of 1.5 (CI:1.2-1.9) for increased risk for [[bipolar disorder]] in a study of 883 Russian patients.

{{ neighbor
| rsid = 4570625
| distance = 230
}}

{{omim
|id=143465
|desc=ATTENTION DEFICIT-HYPERACTIVITY DISORDER; ADHD
|rsnum=11178997
}}

{{omim
|desc=TRYPTOPHAN HYDROXYLASE 2; TPH2
|id=607478
|rsnum=11178997
}}

{{PMID Auto
|PMID=18427560
|Title=Tph2 gene variants modulate response control processes in adult [[ADHD]] patients and healthy individuals
}}

{{omim
|id=125480
|rsnum=11178997
}}

{{omim
|id=613003
|rsnum=11178997
}}

{{PMID Auto
|PMID=22483952
|Title=Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms
}}

{{PMID|16116490}} Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.

{{PMID|17015812}} Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population.

{{PMID|18782386|OA=1
}} Tryptophan hydroxylase 2 gene and alcohol use among college students.

{{PMID|18797398}} Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian population.

{{PMID|20126463|OA=1
}} Alternative splicing and extensive RNA editing of human TPH2 transcripts.

{{PMID|21172166|OA=1
}} Pharmacogenetics of antidepressant response.

{{PMID|22392150}} Common variants in the TPH2 promoter confer susceptibility to paranoid schizophrenia.

{{PMID Auto
|PMID=22655589
|Title=Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.
}}

{{PMID Auto
|PMID=25014617
|Title=TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}