{{Rsnum
|rsid=11188072
|Chromosome=10
|position=96519061
|Orientation=plus
|GMAF=0.1534
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{PharmGKB
|RSID=rs11188072
|Name_s=part of CYP2C19*17; CYP2C19:(-3402)C>T; CYP2C19: -3402C>T
|Gene_s=CYP2C19
|Feature=
|Evidence=PubMed ID:19884907
|Annotation=Risk or phenotype-associated allele: T Phenotype: The CYP2C19*17 allele was associated with significantly increased metabolism of imipramine. Study size: 178 Study population/ethnicity: Psychiatric patients aged 18-65 with a score of greater than or equal to 17 on the Hamilton Rating Scale for Depression. Significance metric(s): p = 0.035 Type of association: PK
|Drugs=imipramine
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165110647
}}

{{PharmGKB
|RSID=rs11188072
|Name_s=CYP2C19: -3402C>T
|Gene_s=CYP2C19
|Feature=
|Evidence=PubMed ID:16413245; PubMed ID:17625515; PubMed ID:18294333
|Annotation=This promoter variant is part of CYP2C19*17 haplotype, which causes increased acitivity and increased transcription of CYP2C19. Patients carrying this allele may exhibit a lack of response to commonly prescribed dosages of certain proton pump inhibitors (PPIs) and antidepressants, due to ultrarapid clearance of these drugs. CYP2C19*17 carriers are more likely to benifit from tamoxifen treatment.
|Drugs=amitriptyline; citalopram; clomipramine; escitalopram; omeprazole; proguanil; tamoxifen
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161615688
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11188072
|overall_frequency_n=25
|overall_frequency_d=128
|overall_frequency=0.195312
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=27
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23661171
|Title=CYP2C19 genotypes and their impact on clopidogrel responsiveness in percutaneous coronary intervention
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}