{{Rsnum
|rsid=11196205
|Gene=TCF7L2
|Chromosome=10
|position=113047288
|Orientation=plus
|GMAF=0.4197
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=TCF7L2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 19.5 | 45.1 | 35.4
| HCB | 0.0 | 5.1 | 94.9
| JPT | 0.9 | 10.6 | 88.5
| YRI | 76.9 | 19.7 | 3.4
| ASW | 66.7 | 33.3 | 0.0
| CHB | 0.0 | 5.1 | 94.9
| CHD | 0.0 | 2.8 | 97.2
| GIH | 11.9 | 46.5 | 41.6
| LWK | 63.6 | 28.2 | 8.2
| MEX | 13.8 | 39.7 | 46.6
| MKK | 43.6 | 43.6 | 12.8
| TSI | 24.8 | 51.5 | 23.8
| HapMapRevision=28
}}

{{PMID|17340123}} [[rs12255372]], [[rs7903146]], [[rs7901695]] and [[rs11196205]] associated with [[type-2 diabetes]]

{{omim
|id=602228
|desc=TRANSCRIPTION FACTOR 7-LIKE 2; TCF7L2
|rsnum=11196205
}}
{{PMID Auto
|PMID=20028944
|Title=Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a risk population for type 2 diabetes
|OA=1
}}

{{omim
|id=602228
|rsnum=11196205
|variant=0003
}}

{{PMID Auto
|PMID=22441719
|Title=Stronger Association of Common Variants in TCF7L2 Gene with Nonobese Type 2 Diabetes in the Latvian Population
}}

{{PMID Auto
|PMID=22511877
|Title=Type 2 Diabetes Risk Alleles Demonstrate Extreme Directional Differentiation among Human Populations, Compared to Other Diseases
|OA=1
}}

{{PMID Auto
|PMID=16936218
|Title=Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.
}}

{{PMID Auto
|PMID=17245589
|Title=A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.
}}

{{PMID Auto
|PMID=17311858
|Title=TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children.
}}

{{PMID Auto
|PMID=17601994
|Title=Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.
}}

{{PMID Auto
|PMID=17609304
|Title=Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese.
}}

{{PMID Auto
|PMID=17661009
|Title=Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=17934151
|Title=A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients.
}}

{{PMID Auto
|PMID=17971425
|Title=Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans.
|OA=1
}}

{{PMID Auto
|PMID=18097733
|Title=Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects.
}}

{{PMID Auto
|PMID=18268068
|Title=Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study.
|OA=1
}}

{{PMID Auto
|PMID=18291022
|Title=Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population.
|OA=1
}}

{{PMID Auto
|PMID=18397358
|Title=TCF7L2 polymorphisms are associated with type 2 diabetes in Khatri Sikhs from North India: genetic variation affects lipid levels.
}}

{{PMID Auto
|PMID=18437354
|Title=TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study.
|OA=1
}}

{{PMID Auto
|PMID=18598350
|Title=Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.
|OA=1
}}

{{PMID Auto
|PMID=18650481
|Title=TCF7L2 variants associate with CKD progression and renal function in population-based cohorts.
|OA=1
}}

{{PMID Auto
|PMID=18655717
|Title=Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.
|OA=1
}}

{{PMID Auto
|PMID=19228405
|Title=Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis.
|OA=1
}}

{{PMID Auto
|PMID=19482368
|Title=Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population.
}}

{{PMID Auto
|PMID=19924244
|Title=TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality.
|OA=1
}}

{{PMID Auto
|PMID=21133856
|Title=Genome-wide association scan allowing for epistasis in type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=21159844
|Title=Variants and haplotypes of TCF7L2 are associated with beta-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1.
}}

{{PMID Auto
|PMID=21423583
|Title=Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosis.
|OA=1
}}

{{PMID Auto
|PMID=23041303
|Title=Association between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population
}}

{{PMID Auto
|PMID=23577093
|Title=Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Hyderabad, India
|OA=1
}}

{{PMID Auto
|PMID=23188737
|Title=TCF7L2 gene polymorphisms and type 2 diabetes risk: a comprehensive and updated meta-analysis involving 121,174 subjects
}}

{{PMID Auto
|PMID=23107111
|Title=Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects.
}}

{{PMID Auto
|PMID=25274455
|Title=The gene polymorphisms of UCP1 but not PPAR γ and TCF7L2 are associated with diabetic retinopathy in Chinese type 2 diabetes mellitus cases
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}