{{Rsnum
|rsid=11203366
|Gene=PADI4
|Chromosome=1
|position=17331039
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.4486
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PADI4
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 33.6 | 46.0 | 20.4
| HCB | 38.7 | 48.9 | 12.4
| JPT | 34.5 | 47.8 | 17.7
| YRI | 19.9 | 47.9 | 32.2
| ASW | 17.5 | 59.6 | 22.8
| CHB | 38.7 | 48.9 | 12.4
| CHD | 39.4 | 47.7 | 12.8
| GIH | 24.8 | 55.4 | 19.8
| LWK | 25.7 | 44.0 | 30.3
| MEX | 21.1 | 50.9 | 28.1
| MKK | 20.0 | 40.6 | 39.4
| TSI | 28.4 | 56.9 | 14.7
| HapMapRevision=28
}}{{Venter SNP
|rsid=11203366
|allele=A
|frequency=0.417
|uid=1103675033959
|type=heterozygous_SNP
|hugo=PADI4
|ensembl gene=ENSG00000159339
|ensembl transcript=ENST00000290507
|sift=TOLERATED
|disease=PADI4 is thought to be a rheumatoid arthritis susceptibility locus (MIM:180300). Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.
}}

{{ neighbor
| rsid = 11203367
| distance = 82
}}

{{PMID Auto
|PMID=20563870
|Title=The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population
}}

{{PMID|18576335|OA=1
}} Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis.

{{PMID|20537173|OA=1
}} Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study.

{{PMID|21039740}} PADI4 gene polymorphism is not associated with ankylosing spondylitis in Chinese Han population.

{{PMID Auto
|PMID=22976394
|Title=Association of single nucleotide polymorphisms (SNPs) of PADI4 gene with rheumatoid arthritis (RA) in Indian population
}}

{{GET Evidence
|gene=PADI4
|aa_change=Gly55Ser
|aa_change_short=G55S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11203366
|overall_frequency_n=5853
|overall_frequency_d=10758
|overall_frequency=0.54406
|n_genomes=36
|n_genomes_annotated=0
|n_haplomes=44
|n_articles=0
|n_articles_annotated=0
|nblosum100=2
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23450494
|Title=[Association of polymorphisms of PTPN22 and PADI4 genes with rheumatoid arthritis in Yunnan]
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}