{{Rsnum
|rsid=11203367
|Gene=PADI4
|Chromosome=1
|position=17331121
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.4421
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=PADI4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 32.7 | 46.9 | 20.4
| HCB | 38.2 | 49.3 | 12.5
| JPT | 34.5 | 47.8 | 17.7
| YRI | 20.4 | 51.7 | 27.9
| ASW | 21.8 | 58.2 | 20.0
| CHB | 38.2 | 49.3 | 12.5
| CHD | 39.4 | 47.7 | 12.8
| GIH | 25.7 | 54.5 | 19.8
| LWK | 25.0 | 49.1 | 25.9
| MEX | 22.4 | 48.3 | 29.3
| MKK | 22.4 | 42.3 | 35.3
| TSI | 27.5 | 57.8 | 14.7
| HapMapRevision=28
}}{{Report GE
|PubMed=12833157
|Source=17265154
|AffyProbeset=SNP_A-1912716
|AffyOrientation=reverse
|AlleleA=A
|AlleleB=G
|onGW5=0
|rsid=11203367
|ancestral=C
|RiskPopulation=Japan
|RiskAllele=T
|CaseFreq=
|ControlFreq=
|OddsRatioHet=
|OddsRatioHom=
|OddsRatioAll=1.97
|Disease=Rheumatoid Arthritis
|DiseaseSymbol=RA
}}

rs11203367 increases susceptibility to Rheumatoid Arthritis 1.26 times for carriers of the T allele {{PMID|17265154}}

rs11203367 increases susceptibility to Rheumatoid Arthritis 1.50 times for carriers of the T allele {{PMID|17265154}}

rs11203367 increases susceptibility to Rheumatoid Arthritis 1.97 times for carriers of the T allele {{PMID|12833157}}
{{Venter SNP
|rsid=11203367
|allele=C
|frequency=0.414
|uid=1103675033958
|type=heterozygous_SNP
|hugo=PADI4
|ensembl gene=ENSG00000159339
|ensembl transcript=ENST00000290507
|sift=TOLERATED
|disease=PADI4 is thought to be a rheumatoid arthritis susceptibility locus (MIM:180300). Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.
}}
{{ neighbor
| rsid = 11203366
| distance = 82
}}

{{PMID Auto
|PMID=20563870
|Title=The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population
}}

{{PMID Auto
|PMID=18576335
|Title=Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=18794853
|Title=Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20537173
|Title=Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study.
|OA=1
}}

{{PMID Auto
|PMID=21039740
|Title=PADI4 gene polymorphism is not associated with ankylosing spondylitis in Chinese Han population.
}}

{{PMID Auto
|PMID=22976394
|Title=Association of single nucleotide polymorphisms (SNPs) of PADI4 gene with rheumatoid arthritis (RA) in Indian population
}}

{{GET Evidence
|gene=PADI4
|aa_change=Val82Ala
|aa_change_short=V82A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11203367
|overall_frequency_n=5942
|overall_frequency_d=10758
|overall_frequency=0.552333
|n_genomes=36
|n_genomes_annotated=0
|n_haplomes=44
|n_articles=0
|n_articles_annotated=0
|nblosum100=2
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}