{{Rsnum
|rsid=11206510
|Chromosome=1
|position=55030366
|Orientation=plus
|GMAF=0.1198
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 1.8 | 29.2 | 69.0
| HCB | 0.0 | 10.9 | 89.1
| JPT | 0.0 | 8.0 | 92.0
| YRI | 2.0 | 18.4 | 79.6
| ASW | 0.0 | 22.8 | 77.2
| CHB | 0.0 | 10.9 | 89.1
| CHD | 0.0 | 6.4 | 93.6
| GIH | 0.0 | 7.9 | 92.1
| LWK | 1.8 | 26.4 | 71.8
| MEX | 0.0 | 15.5 | 84.5
| MKK | 3.2 | 22.4 | 74.4
| TSI | 3.9 | 28.4 | 67.6
| HapMapRevision=28
}}[http://blog.23andme.com/2009/02/09/snpwatch-five-new-studies-identify-genetic-variations-associated-with-coronary-artery-disease-and-heart-attack/ 23andMe blog] [[coronary artery disease]] and [[heart attack]]

SNP 	Risk Version 	Effect 
*[[rs646776]] 	T 	1.19 	
*[[rs17465637]] 	C 	1.14 
*[[rs1746048]] 	C 	1.17 	
*[[rs6725887]] 	C 	1.17 	
*[[rs11206510]] 	T 	1.15 	
*[[rs3184504]] 	T 	1.13 
*[[rs2306374]] 	C 	1.15 
*[[rs3782886]] 	C 	1.44

{{PMID Auto GWAS
|PMID=21378990
|Trait=Coronary heart disease
|Title=Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
|RiskAllele=T
|Pval=9E-8
|OR=1.0800
|ORtxt=[1.05-1.11]
|OA=1
}}
{{PMID Auto GWAS
|PMID=20864672
|Trait=LDL cholesterol
|Title=Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
|RiskAllele=T
|Pval=1E-10
|OR=0.03
|ORtxt=[0.02-0.04] unit increase
|OA=1
}}
{{PMID Auto GWAS
|PMID=19198609
|Trait=Myocardial infarction (early onset)
|Title=Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
|RiskAllele=T
|Pval=1E-8
|OR=1.15
|ORtxt=[1.10-1.21]
|OA=1
}}
{{PMID Auto GWAS
|PMID=19060906
|Trait=LDL cholesterol
|Title=Common variants at 30 loci contribute to polygenic dyslipidemia
|RiskAllele=C
|Pval=4E-8
|OR=0.09
|ORtxt=[0.05-0.13] SD decrease
|OA=1
}}
{{PMID Auto GWAS
|PMID=18193043
|Trait=LDL cholesterol
|Title=Newly identified loci that influence lipid concentrations and risk of coronary artery disease
|RiskAllele=T
|Pval=3.9999999999999998E-11
|OR=3.04
|ORtxt=[NR] mg/dl higher
}}

{{PharmGKB
|RSID=rs11206510
|Name_s=
|Gene_s=PCSK9
|Feature=
|Evidence=PubMed ID:19060906; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants at 30 loci contribute to polygenic dyslipidemia. (Initial Sample Size: 19,840 individuals; Replication Sample Size: Up to 20,623 individuals); (Region: 1p32.3; Reported Gene(s): PCSK9; Risk Allele: rs11206510-C); (p-value= 0.00000004).This variant is associated with LDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740250
}}
{{PharmGKB
|RSID=rs11206510
|Name_s=
|Gene_s=PCSK9
|Feature=
|Evidence=PubMed ID:19198609
|Annotation=In a genome-wide association study this variant (rs11206510) near PCKS9 was associated with with early-onset myocardial infarction in 2,967 cases and 3,075 controls.
|Drugs=
|Drug Classes=
|Diseases=Myocardial Infarction
|Curation Level=Curated
|PharmGKB Accession ID=PA162565805
}}
{{PharmGKB
|RSID=rs11206510
|Name_s=
|Gene_s=PCSK9
|Feature=
|Evidence=PubMed ID:19198609; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. (Initial Sample Size: 2,967 cases, 3,075 controls; Replication Sample Size: 9,746 cases, 9,746 controls); (Region: 1p32.3; Reported Gene(s): PCSK9; Risk Allele: rs11206510-T); (p-value= 0.00000001).This variant is associated with Myocardial infarction (early onset).
|Drugs=
|Drug Classes=
|Diseases=Myocardial Infarction
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739970
}}
{{PMID Auto
|PMID=23380588
|Title=Association between PCSK9 and LDLR gene polymorphisms with coronary heart disease: case-control study and meta-analysis.
}}
{{PMID Auto
|PMID=23202125
|Title=Large-scale association analysis identifies new risk loci for coronary artery disease.
}}
{{PMID Auto
|PMID=23098650
|Title=Impact of variants within seven candidate genes on statin treatment efficacy
}}
{{PMID|22152955|OA=1
}} Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies.

{{PMID|20835900|OA=1
}} Genetics of diabetes complications.
{{PMID Auto
|PMID=20699424
|Title=Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population
|OA=1
}}
{{PMID Auto
|PMID=20576952
|Title=Minor Allele C of Chromosome 1p32 Single Nucleotide Polymorphism rs11206510 Confers Risk of Ischemic Stroke in the Chinese Han Population
}}
{{PMID|20018036|OA=1
}} Using a latent growth curve model for an integrative assessment of the effects of genetic and environmental factors on multiple phenotypes.

{{PMID|19185284|OA=1
}} Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.

{{PMID|19956433|OA=1
}} Genetics of coronary artery disease: focus on genome-wide association studies.

{{PMID|19951432|OA=1
}} Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

{{PMID|19750184|OA=1
}} Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

{{PMID|19435741|OA=1
}} Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.

{{PMID|19060911|OA=1
}} Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.

{{PMID|19060910|OA=1
}} Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

{{PMID|18852197|OA=1
}} Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.

{{PMID|18193044|OA=1
}} Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11206510
|overall_frequency_n=15
|overall_frequency_d=128
|overall_frequency=0.117188
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=16
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}