{{Rsnum
|rsid=11218343
|Gene=SORL1
|Chromosome=11
|position=121564878
|Orientation=plus
|GMAF=0.1198
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SORL1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 6.2 | 93.8
| HCB | 10.9 | 42.3 | 46.7
| JPT | 12.5 | 49.1 | 38.4
| YRI | 0.7 | 10.9 | 88.4
| ASW | 1.8 | 15.8 | 82.5
| CHB | 10.9 | 42.3 | 46.7
| CHD | 6.7 | 43.8 | 49.5
| GIH | 0.0 | 18.8 | 81.2
| LWK | 0.0 | 22.7 | 77.3
| MEX | 0.0 | 21.4 | 78.6
| MKK | 1.9 | 22.6 | 75.5
| TSI | 1.0 | 8.8 | 90.2
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs11218343
|Name_s=
|Gene_s=SORL1
|Feature=
|Evidence=PubMed ID:17553421; PubMed ID:19118814
|Annotation=This variant is nominally associated with late-onset Alzheimer disease (LOAD) in 2 GWAS studies.
|Drugs=
|Drug Classes=
|Diseases=Alzheimer Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA162363856
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11218343
|overall_frequency_n=15
|overall_frequency_d=128
|overall_frequency=0.117188
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=14
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23565137
  |Trait=Alzheimer's disease (late onset)
  |Title=SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
  |RiskAllele=
  |Pval=2E-9
  |OR=1.23
  |ORtxt=[1.15-1.33]
  |OA=1
}}

{{PMID Auto GWAS
  |PMID=24162737
  |Trait=Alzheimer's disease (late onset)
  |Title=Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
  |RiskAllele=T
  |Pval=1E-14
  |OR=1.30
  |ORtxt=[1.22-1.39]
  }}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}