{{Rsnum
|rsid=1121980
|Gene=FTO
|Chromosome=16
|position=53775335
|Orientation=minus
|GMAF=0.3682
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=FTO
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 24.8 | 54.0 | 21.2
| HCB | 67.9 | 27.7 | 4.4
| JPT | 58.4 | 38.1 | 3.5
| YRI | 27.2 | 47.6 | 25.2
| ASW | 22.8 | 50.9 | 26.3
| CHB | 67.9 | 27.7 | 4.4
| CHD | 63.3 | 32.1 | 4.6
| GIH | 40.6 | 50.5 | 8.9
| LWK | 27.3 | 49.1 | 23.6
| MEX | 52.6 | 45.6 | 1.8
| MKK | 14.1 | 59.0 | 26.9
| TSI | 28.4 | 44.1 | 27.5
| HapMapRevision=28
}}[[rs1121980]], a SNP in the [[FTO]] gene, showed the strongest association of several SNPs in the region with early onset [[obesity]] in a study of ~1,000 Caucasians.

The odds ratio for the [[rs1121980(T)]] risk allele was 1.66 (CI: 1.37â€“2.01); and the odds ratios for heterozygotes and homozygotes ([[rs1121980(T;T)]]) were estimated (with a correct p<0.0001) at 1.67 (CI: 1.22â€“2.27) and 2.76 (CI: 1.88â€“4.03), respectively. {{PMID|18159244|OA=1
}}

Note that although [[rs1121980]] showed the strongest association, it is in a block in the [[FTO]] gene of at least 5 other SNPs that are in linkage disequilibrium (r<sup>2</sup>>=0.88 for all). The other 5 SNPs are:
* [[rs9939973]]
* [[rs7193144]]
* [[rs9940128]]
* [[rs8050136]]
* [[rs9939609]]

{{PMID|18379722|OA=1
}} This SNP is also associated with (severe) [[obesity]] in a study of 927 Japanese patients.

{{PMID|19164386|OA=1
}} [[obesity]] and [[type-2 diabetes]]
*[[rs1121980]]
*[[rs7498665]]
*[[rs4752856]]
*[[rs17782313]]
*[[rs2815752]] 
*[[rs10938397]]

{{ neighbor
| rsid = 1477196
| distance = 989
}}

{{PMID Auto GWAS
|PMID=18454148
|Trait=Body mass index
|Title=Common variants near MC4R are associated with fat mass, weight and risk of obesity
|RiskAllele=
|Pval=4.0000000000000001E-8
|OR=0.06
|ORtxt=[0.04-0.08] unit increase in log(BMI)
|OA=1
}}
{{PMID Auto
|PMID=19322589
|Title=Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study
|OA=1
}}

{{PMID Auto
|PMID=19553294
|Title=Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene
}}

{{omim
|desc=BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 14; BMIQ14
|id=612460
|rsnum=1121980
}}

{{PharmGKB
|RSID=rs1121980
|Name_s=
|Gene_s=FTO
|Feature=
|Evidence=PubMed ID:18159244; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants. (Initial Sample Size: 487 young cases, 442 controls; Replication Sample Size: 2,269 individuals in 644 families); (Region: 16q12.2; Reported Gene(s): FTO; Risk Allele: rs1121980-T); (p-value= 9.99999999999999E-08).This variant is associated with Obesity (early onset extreme).
|Drugs=
|Drug Classes=
|Diseases=Obesity
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740861
}}

{{PMID Auto
|PMID=19812171
|Title=Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
}}

{{PMID Auto
|PMID=20075932
|Title=Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese
}}

{{PMID Auto
|PMID=21248185
|Title=Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals
}}

{{omim
|id=601665
|rsnum=1121980
}}

{{PMID Auto
|PMID=22355368
|Title=Longitudinal Replication Studies of GWAS Risk SNPs Influencing Body Mass Index over the Course of Childhood and Adulthood
|OA=1
}}

{{PMID Auto
|PMID=18256137
|Title=Regulation of Fto/Ftm gene expression in mice and humans.
|OA=1
}}

{{PMID Auto
|PMID=18487448
|Title=Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=18599522
|Title=FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.
|OA=1
}}

{{PMID Auto
|PMID=19079261
|Title=Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
|OA=1
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=20017965
|Title=Identifying association under a previous linkage peak on chromosome 16 for body mass index using cross-sectional and longitudinal data of the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=20017980
|Title=A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data.
|OA=1
}}

{{PMID Auto
|PMID=20018076
|Title=Tests for candidate-gene interaction for longitudinal quantitative traits measured in a large cohort.
|OA=1
}}

{{PMID Auto
|PMID=20299471
|Title=FTO genetic variation and association with obesity in West Africans and African Americans.
|OA=1
}}

{{PMID Auto
|PMID=20442772
|Title=Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.
|OA=1
}}

{{PMID Auto
|PMID=20824172
|Title=Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.
|OA=1
}}

{{PMID Auto
|PMID=21102551
|Title=Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort.
}}

{{PMID Auto
|PMID=21115529
|Title=Genetics and genomics of human ageing.
|OA=1
}}

{{PMID Auto
|PMID=22049296
|Title=A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1121980
|overall_frequency_n=59
|overall_frequency_d=126
|overall_frequency=0.468254
|n_genomes=36
|n_genomes_annotated=0
|n_haplomes=48
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23935507
|Title=Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry
|OA=1
}}

{{PMID Auto
|PMID=24106974
|Title=Association between fat mass and obesity-associated (FTO) gene and hip fracture susceptibility
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}