{{Rsnum
|rsid=1126497
|Gene=EPCAM
|Chromosome=2
|position=47373967
|Orientation=plus
|GMAF=0.3398
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=EPCAM
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 22.1 | 54.9 | 23.0
| HCB | 70.1 | 27.7 | 2.2
| JPT | 60.2 | 37.2 | 2.7
| YRI | 89.8 | 9.5 | 0.7
| ASW | 59.6 | 36.8 | 3.5
| CHB | 70.1 | 27.7 | 2.2
| CHD | 66.1 | 30.3 | 3.7
| GIH | 25.7 | 48.5 | 25.7
| LWK | 86.2 | 13.8 | 0.0
| MEX | 19.0 | 58.6 | 22.4
| MKK | 55.5 | 39.4 | 5.2
| TSI | 10.8 | 52.0 | 37.3
| HapMapRevision=28
}}

[[rs1126497]], also known as Thr115Met, is a SNP in the epithelial cell adhesion molecule [[EPCAM]] gene.

In a study of case control study of 1643 individuals with [[breast cancer]] and 1818 control subjects in Eastern and Southern Chinese populations, the [[rs1126497]](T) allele was associated with a 1.4x increased risk (CI: 1.16-1.57), and it was also associated with early [[breast cancer]] onset (p=0.0023). {{PMID|20683652}}

{{PMID|22322561}} Functional polymorphism in the EpCAM gene is associated with occurrence and advanced disease status of cervical cancer in Chinese population.

{{GET Evidence
|gene=EPCAM
|aa_change=Met115Thr
|aa_change_short=M115T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1126497
|overall_frequency_n=6119
|overall_frequency_d=10758
|overall_frequency=0.568786
|n_genomes=42
|n_genomes_annotated=0
|n_haplomes=69
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=2
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24304228
|Title=Polymorphisms of EpCAM gene and prognosis for non-small-cell lung cancer in Han Chinese
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}