{{Rsnum
|rsid=1126671
|Gene=ADH4
|Chromosome=4
|position=99127263
|Orientation=minus
|GMAF=0.18
|Gene_s=ADH4,SLC3A1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 7.1 | 42.5 | 50.4
| HCB | 0.0 | 0.7 | 99.3
| JPT | 0.0 | 1.8 | 98.2
| YRI | 1.4 | 18.4 | 80.3
| ASW | 5.3 | 33.3 | 61.4
| CHB | 0.0 | 0.7 | 99.3
| CHD | 0.0 | 1.8 | 98.2
| GIH | 0.0 | 17.8 | 82.2
| LWK | 4.5 | 29.1 | 66.4
| MEX | 1.7 | 27.6 | 70.7
| MKK | 3.2 | 34.8 | 61.9
| TSI | 11.8 | 46.1 | 42.2
| HapMapRevision=28
}}{{PMID Auto
|PMID=19925625
|Title=Cluster Headache is Associated With the Alcohol Dehydrogenase 4 (ADH4) Gene
}}

{{PMID Auto
|PMID=16220108
|Title=ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies.
}}

{{PMID Auto
|PMID=16685648
|Title=Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.
|OA=1
}}

{{PMID Auto
|PMID=17069770
|Title=Personality traits of agreeableness and extraversion are associated with ADH4 variation.
|OA=1
}}

{{PMID Auto
|PMID=17185388
|Title=Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.
|OA=1
}}

{{PMID Auto
|PMID=17273965
|Title=Evidence of positive selection on a class I ADH locus.
|OA=1
}}

{{PMID Auto
|PMID=18331377
|Title=Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.
|OA=1
}}

{{PMID Auto
|PMID=19193628
|Title=ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.
|OA=1
}}

{{PMID Auto
|PMID=19298322
|Title=Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans.
|OA=1
}}

{{GET Evidence
|gene=ADH4
|aa_change=Ile309Val
|aa_change_short=I309V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1126671
|overall_frequency_n=7874
|overall_frequency_d=10758
|overall_frequency=0.73192
|n_genomes=49
|n_genomes_annotated=0
|n_haplomes=83
|n_articles=0
|n_articles_annotated=0
|nblosum100=-4
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}