{{Rsnum
|rsid=1126742
|Gene=CYP4A11
|Chromosome=1
|position=46932824
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.174
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CYP4A11
}}[[rs1126742]] is a SNP in the [[CYP4A11]] gene, which encodes an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in blood pressure regulation in humans.

In a study of 304 Japanese [[hypertension]] patients, [[rs1126742]](C;T) and (T;T) genotypes were significantly (p=0.022) higher than in control individuals.{{PMID|18300855}}

{{PharmGKB
|RSID=rs1126742
|Name_s=CYP4A11:T8590C; 8610T>C; F434S
|Gene_s=CYP4A11
|Feature=
|Evidence=PubMed ID:15611369; PubMed ID:16144986; PubMed ID:18227405; PubMed ID:18385420
|Annotation=This variant encodes an enzyme with reduced catalytic activity and it is associated with increased risk for essential hypertension. Men with the 8590CC genotype had significantly higher systolic blood pressure and pulse pressure.
|Drugs=
|Drug Classes=
|Diseases=Essential hypertension; Hypertension
|Curation Level=Curated
|PharmGKB Accession ID=PA162355714
}}

{{PMID Auto
|PMID=18484194
|Title=Haplotype-based case study of human CYP4A11 gene and cerebral infarction in Japanese subject.
}}

{{PMID Auto
|PMID=22327816
|Title=A Novel Polymorphism of the CYP4A11 Gene is Associated With Coronary Artery Disease.
}}

{{GET Evidence
|gene=CYP4A11
|aa_change=Phe434Ser
|aa_change_short=F434S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1126742
|overall_frequency_n=1766
|overall_frequency_d=10758
|overall_frequency=0.164157
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=21
|n_articles=0
|n_articles_annotated=0
|nblosum100=5
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=22804341
|Title=Haplotype-based case-control study of CYP4A11 gene and myocardial infarction
}}

{{PMID Auto
|PMID=24164311
|Title=CYP4A11 gene T8590C polymorphism is associated with essential hypertension in the male western Chinese Han population
}}

{{PMID Auto
|PMID=23085321
|Title=Haplotype study of the CYP4A11 gene and coronary artery disease in Han and Uygur populations in China.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}