{{Rsnum
|rsid=1130866
|Gene=SFTPB
|Chromosome=2
|position=85666618
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.4913
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SFTPB
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 19.5 | 47.8 | 32.7
| HCB | 49.6 | 41.6 | 8.8
| JPT | 54.0 | 39.8 | 6.2
| YRI | 5.4 | 24.5 | 70.1
| ASW | 5.3 | 38.6 | 56.1
| CHB | 49.6 | 41.6 | 8.8
| CHD | 52.3 | 39.4 | 8.3
| GIH | 35.6 | 44.6 | 19.8
| LWK | 2.7 | 24.5 | 72.7
| MEX | 27.6 | 53.4 | 19.0
| MKK | 3.8 | 32.7 | 63.5
| TSI | 19.6 | 49.0 | 31.4
| HapMapRevision=28
}}
[[rs1130866]] is a SNP altering an amino acid at position 131 of the pulmonary-associated protein B surfactant [[SFTPB]] gene. On it's own, it does not affect the odds of acquiring systemic sclerosis.

However, in a study of 127 Japanese patients who already had [[systemic sclerosis]], [[rs1130866]](T;T) homozygotes were found to be at reduced risk for interstitial lung disease.{{PMID|18263595}}

{{Venter SNP
|rsid=1130866
|allele=A
|frequency=0.542
|uid=1103658153251
|type=homozygous_SNP
|hugo=SFTPB
|ensembl gene=ENSG00000168878
|ensembl transcript=ENST00000342375
|sift=TOLERATED
|disease=Defects in SFTPB are a cause of congenital pulmonary alveolar proteinosis (PAP) (MIM:265120). PAP is an autosomal recessive fatal respiratory disease.
}}

{{PMID Auto
|PMID=21283003
|Title=The influence of genetic variation in surfactant protein B on severe lung injury in black children
}}

{{PMID|17054776|OA=1
}} The genetics of chronic obstructive pulmonary disease.

{{PMID|17498296|OA=1
}} Surfactant protein B polymorphisms are associated with severe respiratory syncytial virus infection, but not with asthma.

{{PMID|17540055}} No association between coding polymorphism within Exon 4 of the human surfactant protein B gene and pulmonary function in healthy men.

{{PMID|18550614|OA=1
}} Polymorphic variation in surfactant protein B is associated with COPD exacerbations.

{{PMID|18776725|OA=1
}} Developmental and genetic regulation of human surfactant protein B in vivo.

{{PMID|20233420|OA=1
}} Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation.

{{PMID|20693256}} Surfactant protein B polymorphisms, pulmonary function and COPD in 10,231 individuals.

{{GET Evidence
|gene=SFTPB
|aa_change=Thr143Ile
|aa_change_short=T143I
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1130866
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=3
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24337193
|Title=Surfactant protein B gene polymorphism is associated with severe influenza
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}