{{Rsnum
|rsid=1131341
|Gene=NQO1
|Chromosome=16
|position=69714966
|Orientation=plus
|GMAF=0.01699
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=NQO1
}}[[rs1131341]] (C465T, Arg139Trp) is a snp within [[NQO1]] (NAD(P)H dehydrogenase (quinone 1)). A Trp (T) at this location denotes the NQO1*3 allele.

per [[http://www.pharmgkb.org/views/reports/loadVariantReport.action?variantPositionId=6740972#tabview=tab1 pharmgkb]], the NQ1*3 allele is associated with reduced enzyme activity

{{PMID|16266898}} T allele strongly associated (OR = 6.36, CI = 1.84 - 21.90, p = 0.002) with infant acute lymphoblastic leukemia among 103 case infants and 185 controls

{{PharmGKB
|RSID=rs1131341
|Name_s=NQO1:C465T; NQO1:R139W; NQO1*3(T allele)
|Gene_s=NQO1
|Feature=Exon/NonSyn
|Evidence=PubMed ID:17023046; PubMed ID:17179690
|Annotation=T allele causes reduced enzyme activity. May be associated with risk of t-AML and t-MDS. Probably associated with increased risk of ALL;139Arg allele associated with tobacco dose-dependent increase in risk of Head and Neck Squamous Cell Carcinoma.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145101
}}

{{ population diversity
| geno1 = (C;C)
| geno2 = (C;T)
| geno3 = 
| CEU | 92.9 | 7.1 | 0
| CHB | 95.2 | 4.8 | 0
| JPT | 94.1 | 5.9 | 0
| YRI | 99.1 | 0.9 | 0
}}{{PMID Auto
|PMID=15576619
|Title=Hematotoxicity in workers exposed to low levels of benzene.
|OA=1
}}

{{PMID Auto
|PMID=17885617
|Title=Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations.
}}

{{PMID Auto
|PMID=18547414
|Title=Genotyping panel for assessing response to cancer chemotherapy.
|OA=1
}}

{{PMID Auto
|PMID=18632753
|Title=Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.
|OA=1
}}

{{PMID Auto
|PMID=18922824
|Title=Genetic susceptibility to childhood leukaemia.
|OA=1
}}

{{PMID Auto
|PMID=18992148
|Title=Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
|OA=1
}}

{{PMID Auto
|PMID=20663217
|Title=Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China.
|OA=1
}}

{{GET Evidence
|gene=NQO1
|aa_change=Arg139Trp
|aa_change_short=R139W
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1131341
|overall_frequency_n=324
|overall_frequency_d=10758
|overall_frequency=0.0301171
|n_genomes=3
|n_genomes_annotated=0
|n_haplomes=3
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.946
|nblosum100=7
|autoscore=3
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23054000
|Title=Genetic variants in metabolizing genes NQO1, NQO2, MTHFR and risk of prostate cancer: a study from North India.
}}

{{PMID Auto
|PMID=23175176
|Title=Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype.
}}

{{PMID Auto
|PMID=24830960
|Title=Genetic polymorphism 609C&gt;T in NAD(P)H:quinone oxidoreductase 1 enhances the risk of proximal colon cancer
}}
{{on chip | 23andMe v3}}