{{Rsnum
|rsid=1136287
|Gene=SERPINF1
|Chromosome=17
|position=1769982
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.3526
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SERPINF1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 15.0 | 36.3 | 48.7
| HCB | 19.7 | 49.6 | 30.7
| JPT | 23.9 | 52.2 | 23.9
| YRI | 2.7 | 16.3 | 81.0
| ASW | 1.8 | 28.1 | 70.2
| CHB | 19.7 | 49.6 | 30.7
| CHD | 18.3 | 52.3 | 29.4
| GIH | 40.6 | 43.6 | 15.8
| LWK | 1.8 | 28.2 | 70.0
| MEX | 17.2 | 51.7 | 31.0
| MKK | 3.8 | 41.0 | 55.1
| TSI | 12.7 | 44.1 | 43.1
| HapMapRevision=28
}}[[rs1136287]], also known as Met72Thr, is a SNP in the [[PEDF]] gene.

Analysis of 86 Taiwanese Chinese patients with wet [[age related macular degeneration]] (ARMD) found the (T) allele to be more frequent in patients than in controls (50% vs 31%; p =.0005). The [[rs1136287]](T;T) genotype was also more prevalent in patients than in controls (odds ratio 3.9, p = .0015).{{PMID|18226801}}

{{PMID Auto
|PMID=20132989
|Title=Phenotype and Genotype Characteristics of Age-related Macular Degeneration in a Japanese Population
}}

{{PMID Auto
|PMID=20504225
|Title=Pigment Epithelium-Derived Factor Expression in Colorectal Cancer Patients
}}
{{PMID Auto
|PMID=20678803
|Title=Complement Factor H and High-Temperature Requirement A-1 Genotypes and Treatment Response of Age-related Macular Degeneration
}}
{{PMID Auto
|PMID=21174599
|Title=Pigment Epithelium-Derived Factor Gene Polymorphisms in Exudative Age-Related Degeneration in a Chinese Cohort
}}

{{PMID Auto
|PMID=22029535
|Title=Lack of Association with PEDF Met72Thr Variant in Neovascular Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in a Han Chinese Population
}}

{{PMID Auto
|PMID=17658465
|Title=Promoter polymorphisms of the pigment epithelium-derived factor gene are associated with diabetic retinopathy.
}}

{{PMID Auto
|PMID=19223990
|Title=Analysis of three pigment epithelium-derived factor gene polymorphisms in patients with exudative age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=19503741
|Title=Coding variant Met72Thr in the PEDF gene and risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.
|OA=1
}}

{{GET Evidence
|gene=SERPINF1
|aa_change=Thr72Met
|aa_change_short=T72M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1136287
|overall_frequency_n=7664
|overall_frequency_d=10758
|overall_frequency=0.7124
|n_genomes=48
|n_genomes_annotated=0
|n_haplomes=77
|n_articles=0
|n_articles_annotated=0
|nblosum100=2
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23722394
|Title=Evaluation of pigment epithelium-derived factor and complement factor I polymorphisms as a cause of choroidal neovascularization in highly myopic eyes
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}