{{Rsnum
|rsid=1136410
|Gene=PARP1
|Chromosome=1
|position=226367601
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.2443
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=PARP1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 3.5 | 23.0 | 73.5
| HCB | 16.8 | 52.6 | 30.7
| JPT | 25.7 | 40.7 | 33.6
| YRI | 0.0 | 4.8 | 95.2
| ASW | 0.0 | 15.8 | 84.2
| CHB | 16.8 | 52.6 | 30.7
| CHD | 19.3 | 53.2 | 27.5
| GIH | 4.0 | 14.9 | 81.2
| LWK | 0.0 | 12.7 | 87.3
| MEX | 20.7 | 36.2 | 43.1
| MKK | 1.3 | 9.0 | 89.7
| TSI | 1.0 | 18.8 | 80.2
| HapMapRevision=28
}}

[[rs1136410]], also known as V762A, is a SNP in the [[PARP1]] Poly(ADP-ribose) polymerase-1 gene. The [[rs1136410]](C) allele encodes the less common A (alanine) amino acid at this codon.

A study of 1,000 [[glioblastoma]] multiforme cases and 2,000 controls in the US concluded that the [[PARP1]] gene [[rs1136410]](C) allele was associated with a 20% reduction in risk for glioblastoma multiforme (odds ratio 0.80, CI: 0.67-0.95).{{PMID|19318434|OA=1
}}

A meta-analysis of 21 studies with 12,027 cancer patients found no significant association overall between [[rs1136410]] and cancer risk, however, in the stratified analyses, [[rs1136410]](C) was associated with an increased risk of cancer among Asian populations (CT + CC vs. TT: odds ratio 1.11, CI: 1.01-1.23, p(heterogeneity) = 0.210), but a decreased risk of cancer (CT + CC vs. TT: odds ratio 0.89, CI: 0.80-1.00, p(heterogeneity) = 0.004) among Caucasian populations, especially for glioma risk (odds ratio 0.79, CI: 0.69-0.90, p(heterogeneity) = 0.800).{{PMID|22127734|OA=1
}}

{{PMID Auto
|PMID=20150366
|Title=DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma
|OA=1
}}

{{PMID Auto
|PMID=21612407
|Title=Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2
}}

{{PMID Auto
|PMID=21129811
|Title=Associations between polymorphisms in DNA repair genes and TP53 mutations in non-small cell lung cancer
}}

{{PMID Auto
|PMID=16465622
|Title=Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes.
|OA=1
}}

{{PMID Auto
|PMID=16857995
|Title=Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes.
|OA=1
}}

{{PMID Auto
|PMID=17203305
|Title=Genetic variation in the base excision repair pathway and bladder cancer risk.
}}

{{PMID Auto
|PMID=17220334
|Title=High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility.
}}

{{PMID Auto
|PMID=17267408
|Title=Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells.
|OA=1
}}

{{PMID Auto
|PMID=18191955
|Title=Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.
|OA=1
}}

{{PMID Auto
|PMID=18701435
|Title=Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19124499
|Title=Association and interactions between DNA repair gene polymorphisms and adult glioma.
|OA=1
}}

{{PMID Auto
|PMID=19249341
|Title=Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.
|OA=1
}}

{{PMID Auto
|PMID=19822020
|Title=Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.
|OA=1
}}

{{PMID Auto
|PMID=20353610
|Title=Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=20486200
|Title=Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease.
}}

{{PMID Auto
|PMID=21385363
|Title=Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.
|OA=1
}}

{{PMID Auto
|PMID=21420246
|Title=Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.
|OA=1
}}

{{PMID Auto
|PMID=22687647
|Title=Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population.
}}

{{GET Evidence
|gene=PARP1
|aa_change=Val762Ala
|aa_change_short=V762A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1136410
|overall_frequency_n=1322
|overall_frequency_d=10758
|overall_frequency=0.122885
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=14
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.99
|nblosum100=2
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22850545
|Title=Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese
|OA=1
}}

{{PMID Auto
|PMID=23633189
|Title=Involvement of PARP-1 Val762Ala Polymorphism in the Onset of Cervical Cancer in Caucasian Women
|OA=1
}}

{{PMID Auto
|PMID=24500421
|Title=Association between DNA repair gene polymorphisms and risk of glioma: A systematic review and meta-analysis
}}

{{PMID Auto
|PMID=23608917
|Title=Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment.
}}

{{PMID Auto
|PMID=24853559
|Title=PARP-1 Val762Ala Polymorphism and Risk of Cancer: A Meta-Analysis Based on 39 Case-Control Studies
}}

{{PMID Auto
|PMID=24172093
|Title=Polymorphisms in base excision repair genes are associated with endometrial cancer risk among postmenopausal Japanese women
}}

{{PMID Auto
|PMID=25106941
|Title=Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}