{{Rsnum
|rsid=1138272
|Gene=GSTP1
|Chromosome=11
|position=67586108
|Orientation=plus
|GMAF=0.03535
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=GSTP1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 80.5 | 19.5 | 0.0
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 94.7 | 5.3 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 82.2 | 17.8 | 0.0
| LWK | 98.2 | 1.8 | 0.0
| MEX | 87.9 | 10.3 | 1.7
| MKK | 94.2 | 5.8 | 0.0
| TSI | 89.2 | 10.8 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs1138272
|Name_s=GSTP1: C341T; A114V
|Gene_s=GSTP1
|Feature=Exon/NonSyn
|Evidence=PubMed ID:19076156
|Annotation=A study of 124 White patients, which received a high-dose regimen consisting of cyclophosphamide, thiotepa and carboplatin as intravenous infusions, concludes patients homozygous for the GSTP1 C341T allele may have enhanced exposure to thiotepa and tepa.
|Drugs=thiotepa
|Drug Classes=
|Diseases=Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162427746
}}

{{PharmGKB
|RSID=rs1138272
|Name_s=GSTP1: A114V
|Gene_s=GSTP1
|Feature=Exon/NonSyn
|Evidence=Web Resource:http://www.pharmgkb.org/search/annotatedGene/gstp1/variant.jsp
|Annotation=This variant is less well studied and its pharmacogenetic significance is unclear. The variant allele is almost always found in linkage disequilibrium with GSTP1 I105V SNP.
|Drugs=cisplatin; cyclophosphamide; doxorubicin; etoposide; oxaliplatin; pyrimethamine
|Drug Classes=
|Diseases=
|Curation Level=In-Depth
|PharmGKB Accession ID=PA161845839
}}

{{PMID Auto
|PMID=21914837
|Title=Childhood brain tumors and maternal cured meat consumption in pregnancy: differential effect by glutathione S-transferases
|OA=1
}}

{{PMID Auto
|PMID=17160896
|Title=Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants.
|OA=1
}}

{{PMID Auto
|PMID=17194543
|Title=Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease.
|OA=1
}}

{{PMID Auto
|PMID=17601350
|Title=A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
|OA=1
}}

{{PMID Auto
|PMID=17686149
|Title=Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery.
|OA=1
}}

{{PMID Auto
|PMID=18191955
|Title=Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.
|OA=1
}}

{{PMID Auto
|PMID=18559526
|Title=Glutathione s-transferase p1: gene sequence variation and functional genomic studies.
|OA=1
}}

{{PMID Auto
|PMID=18601742
|Title=Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.
|OA=1
}}

{{PMID Auto
|PMID=18709160
|Title=Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease.
|OA=1
}}

{{PMID Auto
|PMID=18776599
|Title=Susceptibility genes for gentamicin-induced vestibular dysfunction.
|OA=1
}}

{{PMID Auto
|PMID=18854777
|Title=Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.
|OA=1
}}

{{PMID Auto
|PMID=18992148
|Title=Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
|OA=1
}}

{{PMID Auto
|PMID=20049130
|Title=Black carbon exposure, oxidative stress genes, and blood pressure in a repeated-measures study.
|OA=1
}}

{{PMID Auto
|PMID=20459744
|Title=Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study.
|OA=1
}}

{{PMID Auto
|PMID=20540773
|Title=The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer.
|OA=1
}}

{{PMID Auto
|PMID=21741876
|Title=Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk.
}}

{{PMID Auto
|PMID=22661588
|Title=Antioxidant enzyme polymorphisms and neuropsychological outcomes in medulloblastoma survivors: a report from the Childhood Cancer Survivor Study.
|OA=1
}}

{{GET Evidence
|gene=GSTP1
|aa_change=Ala114Val
|aa_change_short=A114V
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=recessive
|quality_scores=Array
|dbsnp_id=rs1138272
|overall_frequency_n=636
|overall_frequency_d=10292
|overall_frequency=0.0617956
|n_genomes=3
|n_genomes_annotated=0
|n_haplomes=3
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|pph2_score=0.018
|nblosum100=2
|autoscore=1
|webscore=N
|summary_short=Increased exposure to thiotepa.
}}

{{PMID Auto
|PMID=24465030
|Title=GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study
|OA=1
}}

{{PMID Auto
|PMID=24610081
|Title=Associations Between SNPs Within Antioxidant Genes and the Risk of Prostate Cancer in the Siberian Region of Russia
}}

{{PMID Auto
|PMID=22487578
|Title=Association of glutathione S-transferase pi isoform single-nucleotide polymorphisms with exudative age-related macular degeneration in a Chinese population.
}}

{{PMID Auto
|PMID=22868256
|Title=A prospective validation pharmacogenomic study in the adjuvant setting of colorectal cancer patients treated with the 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX4) regimen.
|OA=1
}}

{{PMID Auto
|PMID=23175176
|Title=Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype.
}}

{{PMID Auto
|PMID=23179585
|Title=Possible contribution of GSTP1 and other xenobiotic metabolizing genes to vitiligo susceptibility.
}}

{{PMID Auto
|PMID=23663310
|Title=Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}