{{Rsnum
|rsid=113993961
|Gene=WRN
|Chromosome=8
|position=31141680
|Orientation=plus
|GMAF=0.0004591
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=Werner Syndrome
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=WRN
}}[[rs113993961]] is a rare transversion in the [[WRN]] gene that results in a frameshift of codons 1078 to 1092 due to a change in a splice donor sequence, leading to the recessive disorder known as [[Werner Syndrome]]. See [http://www.ncbi.nlm.nih.gov/omim/604611#604611Variants0004 OMIM 604611.0004].
{{omim
|id=604611
|rsnum=113993961
|variant=0004
}}{{ClinVar
|rsid=113993961
|Reversed=0
|FwdREF=G
|FwdALT=C
|REF=G
|ALT=C
|RSPOS=30999196
|CHROM=8
|GMAF=0.0005
|dbSNPBuildID=132
|SSR=0
|SAO=1
|VP=0x050168000000000016110100
|GENEINFO=WRN:7486
|GENE_NAME=WRN
|GENE_ID=7486
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000008.10:g.30999196G>C
|CLNSRC=GeneReviews; OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=NBK1514; 604611.0004
|CLNSIG=5
|CLNCUI=C0043119
|CLNDBN=Werner syndrome; not provided
|Disease=Werner syndrome; not provided
|CLNACC=RCV000005780.1; RCV000058932.1
|Tags=PM;PMC;SLO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.9995; 0.0004591
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet:SNOMED_CT
|CLNDSDBID=NBK1514:C0043119:277700:902:51626007
|COMMON=0
}}{{PMID Auto
|PMID=10347997
|Title=Prevalence of Werner's syndrome heterozygotes in Japan.
}}

{{PMID Auto
|PMID=16673358
|Title=The spectrum of WRN mutations in Werner syndrome patients.
|OA=1
}}