{{Rsnum
|rsid=1143627
|Gene=IL1B
|Chromosome=2
|position=112836810
|Orientation=minus
|GMAF=0.4803
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=IL1B
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 13.3 | 46.0 | 40.7
| HCB | 24.3 | 43.4 | 32.4
| JPT | 23.9 | 43.4 | 32.7
| YRI | 46.9 | 39.5 | 13.6
| ASW | 43.9 | 42.1 | 14.0
| CHB | 24.3 | 43.4 | 32.4
| CHD | 27.5 | 47.7 | 24.8
| GIH | 33.7 | 52.5 | 13.9
| LWK | 51.8 | 42.7 | 5.5
| MEX | 27.6 | 48.3 | 24.1
| MKK | 40.4 | 46.2 | 13.5
| TSI | 12.7 | 49.0 | 38.2
| HapMapRevision=28
}}{{PMID|16508980}} associated with ankylosing spondylitis

{{PMID|16961803}} risk of Helicobacter pylori infection. Children carrying IL1A-889T had a lower risk of H. pylori positivity, compared to those carrying -889C, with each T allele associated with 43% risk reduction (OR = 0.57, 95% CI = 0.33-0.99, p-trend = .05)

upregulation of pro-inflammatory cytokines may protect against persistent H. pylori colonization.

{{ neighbor
| rsid = 16944
| distance = 480
}}

{{PMID Auto
|PMID=19280228
|Title=Interleukin-1 cluster gene polymorphisms in childhood IgA nephropathy
}}
{{PMID Auto
|PMID=19733643
|Title=Interleukin-1 region meta-analysis with osteoarthritis phenotypes
}}
{{PMID Auto
|PMID=19793334
|Title=Association of the -31C/T functional polymorphism in the interleukin-1beta gene with the intractability of Graves' disease and the proportion of T helper type 17 cells
|OA=1
}}

{{PMID Auto
|PMID=20509889
|Title=The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study
|OA=1
}}

{{PMID Auto
|PMID=21445572
|Title=Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
}}

{{PMID Auto
|PMID=21992747
|Title=Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study
|OA=1
}}

{{PMID Auto
|PMID=21968104
|Title=The association of genetic variants in interleukin-1 genes with cognition: findings from the cardiovascular health study
|OA=1
}}

{{PMID|16078996|OA=1
}} Association study of functional genetic variants of innate immunity related genes in celiac disease.

{{PMID|17327408|OA=1
}} Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

{{PMID|17356794}} Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract.

{{PMID|17532232}} Potential influence of IL1B haplotype and IL1A-IL1B-IL1RN extended haplotype on hand osteoarthritis risk.

{{PMID|17592300|OA=1
}} Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype.

{{PMID|17601350|OA=1
}} A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

{{PMID|17705862|OA=1
}} Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

{{PMID|18464913|OA=1
}} A genome-wide association study identifies protein quantitative trait loci (pQTLs).

{{PMID|18576312|OA=1
}} A broad analysis of IL1 polymorphism and rheumatoid arthritis.

{{PMID|18633131|OA=1
}} Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

{{PMID|18676870|OA=1
}} Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

{{PMID|18757527|OA=1
}} Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer.

{{PMID|18842150|OA=1
}} Concurrent genotyping of Helicobacter pylori virulence genes and human cytokine SNP sites using whole genome amplified DNA derived from minute amounts of gastric biopsy specimen DNA.

{{PMID|19016479}} Tagging SNP association study of the IL-1beta gene (IL1B) and childhood-onset mood disorders.

{{PMID|19043479|OA=1
}} Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.

{{PMID|19066394|OA=1
}} Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

{{PMID|19092239|OA=1
}} Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation.

{{PMID|19356949|OA=1
}} Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

{{PMID|19734419|OA=1
}} A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support.

{{PMID|20012999|OA=1
}} The cancer anorexia/weight loss syndrome: exploring associations with single nucleotide polymorphisms (SNPs) of inflammatory cytokines in patients with non-small cell lung cancer.

{{PMID|20437198}} Three polymorphisms in interleukin-1beta gene and risk for breast cancer: a meta-analysis.

{{PMID|20463618|OA=1
}} Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

{{PMID|20811626|OA=1
}} Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

{{PMID|21111021}} Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine.

{{PMID|21172166|OA=1
}} Pharmacogenetics of antidepressant response.

{{PMID|21240526}} Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review.

{{PMID|21385363|OA=1
}} Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.

{{PMID|21448414|OA=1
}} Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease.

{{PMID|21880580}} Interaction between functional polymorphic variants in cytokine genes, established risk factors and susceptibility to basal cell carcinoma of skin.

{{PMID Auto
|PMID=23592922
|Title=Interleukin 1 beta promoter polymorphism is associated with keratoconus in a Japanese population
|OA=1
}}

{{PMID Auto
|PMID=24194923
|Title=Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study
|OA=1
}}

{{PMID Auto
|PMID=23927441
|Title=Genetic variants in IL1A and IL1B contribute to the susceptibility to 2009 pandemic H1N1 influenza A virus
|OA=1
}}

{{PMID Auto
|PMID=22858724
|Title=IL1B and VWF variants are associated with fibrinolytic early recanalization in patients with ischemic stroke.
}}

{{PMID Auto
|PMID=23029430
|Title=Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.
|OA=1
}}

{{PMID Auto
|PMID=25222025
|Title=Interleukin-1β-31C/T and -511T/C Polymorphisms Were Associated with Preeclampsia in Chinese Han Population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}