{{Rsnum
|rsid=1143679
|Gene=ITGAM
|Chromosome=16
|position=31265490
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.08815
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ITGAM
}}Causal SNP in the [[ITGAM]] (CD11b) gene in patients with [[SLE]] who are of European or African descent;(P = 1.7 x 10(-17), odds ratio = 1.78).{{PMID|18204448}}

{{PMID|19129174|OA=1
}} reconfirmed

{{omim
|desc=SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 6; SLEB6
|id=609939
|rsnum=1143679
}}

{{omim
|desc=SYSTEMIC LUPUS ERYTHEMATOSUS; SLE
|id=152700
|rsnum=1143679
}}

{{omim
|id=120980
|desc=INTEGRIN, ALPHA-M; ITGAM
|rsnum=1143679
}}
{{PMID Auto
|PMID=19714582
|Title=Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors
}}

{{PMID Auto
|PMID=19939855
|Title=ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash, and immunologic manifestations in lupus patients with European ancestry
|OA=1
}}

{{PharmGKB
|RSID=rs1143679
|Name_s=ITGAM: R77H
|Gene_s=ITGAM
|Feature=
|Evidence=PubMed ID:18204448
|Annotation=This nonsynonymous SNP is an associated with risk of systemic lupus erythematosus in a study with 3,818 individuals of European descent.
|Drugs=
|Drug Classes=
|Diseases=Lupus Erythematosus, Systemic
|Curation Level=Curated
|PharmGKB Accession ID=PA161925611
}}

{{PMID Auto
|PMID=21840425
|Title=Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases
|OA=1
}}

{{PMID Auto
|PMID=21362770
|Title=Association study of ITGAM, ITGAX, and CD58 autoimmune risk loci in systemic sclerosis: results from 2 large European Caucasian cohorts
|OA=1
}}

{{PMID Auto
|PMID=22523428
|Title=Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries
|OA=1
}}

{{PMID Auto
|PMID=22586164
|Title=The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes.
|OA=1
}}

{{PMID Auto
|PMID=19286673
|Title=ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai.
|OA=1
}}

{{PMID Auto
|PMID=19442287
|Title=Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=19849816
|Title=Genetics of rheumatic disease.
|OA=1
}}

{{PMID Auto
|PMID=20629846
|Title=Association of ITGAM polymorphism with systemic lupus erythematosus: a meta-analysis.
}}

{{PMID Auto
|PMID=20666624
|Title=ITGAM Arg77His is associated with disease susceptibility, arthritis, and renal symptoms in systemic lupus erythematosus patients from a sample of the Polish population.
}}

{{PMID Auto
|PMID=21965647
|Title=A nonsynonymous functional variant of the ITGAM gene is not involved in biopsy-proven giant cell arteritis.
}}

{{GET Evidence
|gene=ITGAM
|aa_change=Arg77His
|aa_change_short=R77H
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1143679
|overall_frequency_n=1085
|overall_frequency_d=10304
|overall_frequency=0.105299
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=11
|n_articles=1
|n_articles_annotated=1
|in_omim=Y
|in_pharmgkb=Y
|pph2_score=0.048
|nblosum100=1
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23386618
|Title=Complement receptor 3 influences Toll-like receptor 7/8 dependent inflammation: implications for autoimmune diseases characterized by antibody reactivity to ribonucleoproteins
|OA=1
}}

{{PMID Auto
|PMID=23451151
|Title=Phagocytosis Is the Main CR3-Mediated Function Affected by the Lupus-Associated Variant of CD11b in Human Myeloid Cells
|OA=1
}}

{{PMID Auto
|PMID=24264377
|Title=Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance
}}

{{PMID Auto
|PMID=22922229
|Title=Seven newly identified loci for autoimmune thyroid disease.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}