{{Rsnum
|rsid=11465804
|Gene=IL23R
|Chromosome=1
|position=67236843
|Orientation=plus
|GMAF=0.03903
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=IL23R
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 0.0 | 8.9 | 91.1
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.7 | 4.8 | 94.5
| ASW | 0.0 | 8.8 | 91.2
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 5.5 | 94.5
| MEX | 1.7 | 15.5 | 82.8
| MKK | 1.3 | 13.5 | 85.3
| TSI | 1.0 | 15.7 | 83.3
| HapMapRevision=28
}}
[[rs11465804]] is one of several SNPs in the [[IL23R]] gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with [[ankylosing spondylitis]]. The odds ratio is 0.68 (p=0.0002).[PMID 17952073, PMID 18037607]

{{GWAS Summary
|SNP=rs11465804
|PubMedID=17804789
|Condition=Crohn's disease
|Gene=IL23R
|Risk Allele=
|pValue=1.00E-008
|OR=1.38
|95CI=1.23-1.53
|OA=1
}}

{{PMID Auto GWAS
|PMID=18587394
|Trait=Crohn's disease
|Title=Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease
|RiskAllele=T
|Pval=7.0000000000000001E-63
|OR=2.50
|ORtxt=[NR]
|OA=1
}}

{{PharmGKB
|RSID=rs11465804
|Name_s=
|Gene_s=IL23R
|Feature=
|Evidence=PubMed ID:17804789; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci (Initial Sample Size: 382 trios; Replication Sample Size: 521 trios, 750 cases, 828 controls). This variant is associated with Crohn's disease. This variant is associated with Crohn's disease.
|Drugs=
|Drug Classes=
|Diseases=Crohn Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356492
}}

{{PMID Auto GWAS
|PMID=20570966
|Trait=Crohn's disease
|Title=Fucosyltransferase 2(FUT2) Non-Secretor Status is associated with Crohn's Disease
|RiskAllele=
|Pval=0.000001
|OR=1.89
|ORtxt=[1.47-2.44]
|OA=1
}}

{{PMID Auto
|PMID=22089529
|Title=Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis
}}

{{PMID Auto
|PMID=22269043
|Title=Clinical predictors of inflammatory bowel disease in a genetically well-defined Caucasian population
|OA=1
}}

{{PMID Auto
|PMID=22440928
|Title=Perianal Crohn's Disease: Predictive Factors and Genotype-Phenotype Correlations
|OA=1
}}

{{PMID Auto
|PMID=17068223
|Title=A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
}}

{{PMID Auto
|PMID=17447842
|Title=Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.
|OA=1
}}

{{PMID Auto
|PMID=17786191
|Title=rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.
|OA=1
}}

{{PMID Auto
|PMID=18047539
|Title=Association between genetic variants in the IL-23R gene and early-onset Crohn's disease: results from a case-control and family-based study among Canadian children.
}}

{{PMID Auto
|PMID=18369459
|Title=A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
|OA=1
}}

{{PMID Auto
|PMID=18383363
|Title=Association of interleukin-23 receptor variants with ankylosing spondylitis.
}}

{{PMID Auto
|PMID=18758464
|Title=Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.
|OA=1
}}

{{PMID Auto
|PMID=19122664
|Title=Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=19175939
|Title=IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.
|OA=1
}}

{{PMID Auto
|PMID=19189980
|Title=Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta-analysis of published series.
}}

{{PMID Auto
|PMID=19408013
|Title=Strategies and issues in the detection of pathway enrichment in genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=19468064
|Title=Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.
|OA=1
}}

{{PMID Auto
|PMID=19557189
|Title=Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
|OA=1
}}

{{PMID Auto
|PMID=19918037
|Title=Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis.
|OA=1
}}

{{PMID Auto
|PMID=20018022
|Title=Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in Genetic Analysis Workshop 16 rheumatoid arthritis data.
|OA=1
}}

{{PMID Auto
|PMID=20454450
|Title=Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
|OA=1
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11465804
|overall_frequency_n=636
|overall_frequency_d=10758
|overall_frequency=0.0591188
|n_genomes=4
|n_genomes_annotated=0
|n_haplomes=5
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23725363
|Title=Predicting complicated Crohn's disease and surgery: phenotypes, genetics, serology and psychological characteristics of a population-based cohort.
}}

{{PMID Auto
|PMID=24998354
|Title=Determination of IL-23 receptor gene polymorphism in Iranian patients with ankylosing spondylitis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}