{{Rsnum
|rsid=1154155
|Gene=TRA
|Chromosome=14
|position=22533736
|Orientation=plus
|GMAF=0.2365
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 2.7 | 23.9 | 73.5
| HCB | 27.0 | 49.6 | 23.4
| JPT | 24.8 | 46.9 | 28.3
| YRI | 0.7 | 7.5 | 91.8
| ASW | 0.0 | 15.8 | 84.2
| CHB | 27.0 | 49.6 | 23.4
| CHD | 28.4 | 50.5 | 21.1
| GIH | 3.0 | 24.8 | 72.3
| LWK | 0.0 | 7.3 | 92.7
| MEX | 0.0 | 39.7 | 60.3
| MKK | 0.6 | 16.7 | 82.7
| TSI | 4.0 | 32.7 | 63.4
| HapMapRevision=28
}}
[[rs1154155]] is a SNP in the [[TCRA]] T-cell receptor alpha gene. The minor allele is (G).

A study of 1,830 people with [[narcolepsy]] and cataplexy (a sudden loss of muscle tone that can cause people to collapse) compared to 2,164 healthy controls concluded that several SNPs in the TCRA gene were linked. The most significant association was with this SNP, [[rs1154155]], with an 
average allelic odds ratio of 1.69 (genotypic odds ratios 1.94 and 2.55, p < 10e-21).{{PMID|19412176|OA=1
}}

Note the following, though, as quoted from a [http://www.usnews.com/articles/science/2009/05/06/narcolepsy-the-sleep-disorder-linked-to-immune-system-problem.html Science News article]: "Even with all of the known genetic risk factors, including the newly discovered version of the T cell receptor gene, a person has only a 1.5 percent chance of developing narcolepsy.... That suggests that, while narcolepsy is probably an autoimmune disorder, further genetic and environmental triggers and risk factors remain to be found."

[[HLA-DQB1*0602]] and relevance to [[Narcolepsy]] related to vaccination

{{PMID Auto
|PMID=19927159
|Title=Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype
}}

{{PMID Auto GWAS
|PMID=20711174
|Trait=None
|Title=Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy
|RiskAllele=G
|Pval=5E-7
|OR=1.54
|ORtxt=[1.30-1.95]
}}

{{omim
|id=612851
|rsnum=1154155
}}

{{PMID|22177342|OA=1
}} TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1154155
|overall_frequency_n=16
|overall_frequency_d=128
|overall_frequency=0.125
|n_genomes=12
|n_genomes_annotated=0
|n_haplomes=15
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=24204295
  |Trait=Narcolepsy
  |Title=Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
  |RiskAllele=G
  |Pval=5E-49
  |OR=1.64
  |ORtxt=[1.53-1.75]
  |OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}