{{Rsnum
|rsid=1154233
|Gene=LAMA3
|Chromosome=18
|position=23931125
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=LAMA3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 0.0 | 100.0
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.9 | 8.3 | 90.7
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 2.0 | 98.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 2.0 | 98.0
| TSI | 0.0 | 3.0 | 97.0
| HapMapRevision=28
}}

{{Venter SNP
|rsid=1154233
|allele=G
|frequency=1
|uid=1103645154355
|type=homozygous_SNP
|hugo=LAMA3
|ensembl gene=ENSG00000053747
|ensembl transcript=ENST00000269217
|sift=TOLERATED
|disease=Defects in LAMA3 are the cause of laryngoonychocutaneous syndrome (LOCS) (MIM:245660). LOCS is an autosomal recessive epithelial disorder confined to the Punjabi Muslim population. The condition is characterized by cutaneous erosions, nail dystrophy and exuberant vascular granulation tissue in certain epithelia, especially conjunctiva and larynx.
}}

{{GET Evidence
|gene=LAMA3
|aa_change=Ser2834Gly
|aa_change_short=S2834G
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1154233
|overall_frequency_n=124
|overall_frequency_d=124
|overall_frequency=1
|n_genomes=56
|n_genomes_annotated=0
|n_haplomes=110
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=3
|qualitycomment_in_silico=Y
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=2
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}