{{Rsnum
|rsid=11558538
|Gene=HNMT
|Chromosome=2
|position=138002079
|Orientation=plus
|GMAF=0.05601
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=HNMT
}}{{PMID Auto
|PMID=19773194
|Title=Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor
|OA=1
}}

{{omim
|id=605238
|rsnum=11558538
|variant=0001
}}
{{ population diversity
| geno1 = (C;C)
| geno2 = (C;T)
| geno3 = (T;T)
| CEU | 76.7 | 21.7 | 1.7
| CHB | 91.1 | 8.9 | 0.0
| JPT | 95.6 | 4.4 | 0.0
| YRI | 100.0 | 0.0 | 0.0
}}{{ClinVar
|rsid=11558538
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=138759649
|CHROM=2
|GMAF=0.0559
|dbSNPBuildID=120
|SSR=0
|SAO=1
|VP=0x05037800000015051e110100
|GENEINFO=HNMT:3176
|GENE_NAME=HNMT
|GENE_ID=3176
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000002.11:g.138759649C>T
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=605238.0001
|CLNSIG=255
|CLNCUI=CN029238
|CLNDBN=Asthma, susceptibility to
|Disease=Asthma
|CLNACC=RCV000005467.1
|Tags=PM;TPA;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;LSD;OM
|CAF=0.944; 0.05601
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C1869116:600807
|COMMON=1
}}{{GET Evidence
|gene=HNMT
|aa_change=Thr105Ile
|aa_change_short=T105I
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=other
|quality_scores=Array
|dbsnp_id=rs11558538
|overall_frequency_n=828
|overall_frequency_d=10758
|overall_frequency=0.076966
|n_genomes=8
|n_genomes_annotated=0
|n_haplomes=7
|n_articles=6
|n_articles_annotated=5
|qualityscore_in_silico=1
|qualitycomment_in_silico=Y
|qualityscore_in_vitro=2
|qualitycomment_in_vitro=Y
|qualityscore_case_control=0
|qualitycomment_case_control=Y
|qualityscore_severity=2
|qualityscore_treatability=3
|in_omim=Y
|pph2_score=0.821
|nblosum100=3
|autoscore=2
|webscore=N
|summary_short=Initial reports implicated this in causing increased susceptibility to asthma, but later reports contradict this. The variant does not appear to be significantly pathogenic, despite computational and experimental evidence that the variant affects enzyme activity.
}}