{{Rsnum
|rsid=11568350
|Gene=SLC40A1
|Chromosome=2
|position=189565370
|Orientation=plus
|GMAF=0.009642
|Gene_s=SLC40A1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 100.0 | 0.0 | 0.0
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 91.7 | 8.3 | 0.0
| ASW | 84.2 | 15.8 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 93.5 | 6.5 | 0.0
| MEX | 98.2 | 1.8 | 0.0
| MKK | 98.1 | 1.9 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

Ferroportin is the only currently known cellular iron exporter. It is a transmembrane protein responsible for iron export from enterocytes, macrophages, and many other cell types. 

[[rs11568350]]: Mutation c.744G → T mutation in exon 6 of the [[SLC40A1]] gene, resulting in Q248H amino acid substitution in the ferroportin-1 protein. The more common [[rs11568350]](G) allele encodes the Q (glutamine) at this codon, while the less common [[rs11568350]](T) encodes the H (histidine). The Q248H polymorphism is found primarily in populations of African origin {{PMID|21231898}}. 

In one study of 200 HIV-positive women in Rwanda, [[rs11568350]](G;T) heterozygotes (i.e. Q248H carriers) had significantly higher values for serum ferritin (p=0.001) and significantly lower values for serum hepcidin (p=0.001) and transferrin (p=0.01) compared to [[rs11568350]](G;G) homozygotes. They may also have been prone to higher prevalence of some opportunistic infections.
{{PMID|22249207}}

{{GET Evidence
|gene=SLC40A1
|aa_change=Gln248His
|aa_change_short=Q248H
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11568350
|overall_frequency_n=213
|overall_frequency_d=10758
|overall_frequency=0.0197992
|n_genomes=5
|n_genomes_annotated=0
|n_haplomes=5
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=-1
|autoscore=3
|n_web_uneval=10
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}