{{Rsnum
|rsid=11572103
|Gene=CYP2C8
|Chromosome=10
|position=96818106
|Orientation=minus
|GMAF=0.03903
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 100.0 | 0.0 | 0.0
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 63.9 | 32.8 | 3.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs11572103
|Name_s=CYP2C8: I269F; A805T
|Gene_s=CYP2C8
|Feature=Exon/NonSyn
|Evidence=PubMed ID:11668219
|Annotation=The variant is part of the CYP2C8*2 allele. In an in vitro study, the CYP2C8*2 allele exhibited a two-fold lower clearance for paclitaxel than the wildtype.
|Drugs=paclitaxel
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161660770
}}

{{PMID Auto
|PMID=22531455
|Title=Distribution of human CYP2C8*2 allele in three different African populations
|OA=1
}}

{{PMID Auto
|PMID=19761371
|Title=Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies.
|OA=1
}}

{{PMID Auto
|PMID=20389299
|Title=Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.
|OA=1
}}

{{GET Evidence
|gene=CYP2C8
|aa_change=Ile269Phe
|aa_change_short=I269F
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=recessive
|quality_scores=Array
|dbsnp_id=rs11572103
|overall_frequency_n=604
|overall_frequency_d=10758
|overall_frequency=0.0561443
|n_genomes=8
|n_genomes_annotated=0
|n_haplomes=8
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|pph2_score=0.516
|nblosum100=2
|autoscore=1
|webscore=N
|summary_short=2x lower clearance for paclitaxel.
}}

{{PMID Auto
|PMID=23133420
|Title=Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}