{{Rsnum
|rsid=11574637
|Gene=ITGAX
|Chromosome=16
|position=31357553
|Orientation=plus
|GMAF=0.1579
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ITGAX
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 2.7 | 23.0 | 74.3
| HCB | 0.0 | 1.5 | 98.5
| JPT | 0.0 | 0.0 | 100.0
| YRI | 11.6 | 46.3 | 42.2
| ASW | 5.3 | 33.3 | 61.4
| CHB | 0.0 | 1.5 | 98.5
| CHD | 0.0 | 3.7 | 96.3
| GIH | 4.0 | 42.6 | 53.5
| LWK | 11.8 | 36.4 | 51.8
| MEX | 3.4 | 15.5 | 81.0
| MKK | 3.2 | 32.5 | 64.3
| TSI | 2.9 | 39.2 | 57.8
| HapMapRevision=28
}}

Associated with systemic [[lupus]] erythematosus ([[SLE]]) {{PMID|18204098}}

{{GWAS Summary
|SNP=rs11574637
|PubMedID=18204098
|Condition=Systemic lupus erythematosus
|Gene=ITGAM, ITGAX
|Risk Allele=C
|pValue=3.00E-011
|OR=1.33
|95CI=1.22-1.46
}}

{{omim
|desc=SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 6; SLEB6
|id=609939
|rsnum=11574637
}}

{{omim
|id=151510
|desc=INTEGRIN, ALPHA-X; ITGAX
|rsnum=11574637
}}

{{PharmGKB
|RSID=rs11574637
|Name_s=
|Gene_s=ITGAX
|Feature=
|Evidence=PubMed ID:18204098; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX (Initial Sample Size: 1,311 cases, 3,340 controls; Replication Sample Size: 793 cases, 857 controls; Risk Allele: rs11574637-C).
|Drugs=
|Drug Classes=
|Diseases=Lupus erythematosus; Lupus Erythematosus, Systemic
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356731
}}

{{PMID Auto
|PMID=21362770
|Title=Association study of ITGAM, ITGAX, and CD58 autoimmune risk loci in systemic sclerosis: results from 2 large European Caucasian cohorts
|OA=1
}}

{{PMID Auto
|PMID=19129174
|Title=Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).
|OA=1
}}

{{PMID Auto
|PMID=19286673
|Title=ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai.
|OA=1
}}

{{PMID Auto
|PMID=19997561
|Title=Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE).
|OA=1
}}

{{PMID Auto
|PMID=20629846
|Title=Association of ITGAM polymorphism with systemic lupus erythematosus: a meta-analysis.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11574637
|overall_frequency_n=26
|overall_frequency_d=128
|overall_frequency=0.203125
|n_genomes=24
|n_genomes_annotated=0
|n_haplomes=27
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}