{{Rsnum
|rsid=11614913
|Gene=MIR196A2
|Chromosome=12
|position=53991815
|Orientation=plus
|GMAF=0.388
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=MIR196A2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 33.6 | 44.2 | 22.1
| HCB | 20.4 | 48.9 | 30.7
| JPT | 15.9 | 46.9 | 37.2
| YRI | 74.1 | 24.5 | 1.4
| ASW | 59.6 | 35.1 | 5.3
| CHB | 20.4 | 48.9 | 30.7
| CHD | 16.5 | 45.0 | 38.5
| GIH | 48.5 | 46.5 | 5.0
| LWK | 76.4 | 22.7 | 0.9
| MEX | 36.8 | 45.6 | 17.5
| MKK | 49.7 | 45.2 | 5.2
| TSI | 40.2 | 49.0 | 10.8
| HapMapRevision=28
}}{{PMID|18521189|OA=1
}}  [[miRNA]] sequences and non-small cell [[lung cancer]]

[[rs11614913]] SNP in hsa-mir-196a2 was associated with survival in individuals with NSCLC. Specifically, survival was significantly decreased in individuals who were homozygous CC at SNP rs11614913.

{{PMID|18634034}} [[microRNA]] 1,009 breast cancer cases and 1,093 controls in a population of Chinese women
*[[rs11614913]] in [[hsa-mir-196a2]] T>C 1.23; 95% confidence interval [CI], 1.02-1.48 
*[[rs3746444]] in [[hsa-mir-499]] A>G OR 1.25; 95% CI, 1.02-1.51

{{snp near feature
| rsid = 11614913
| type = microRNA
| ACC=MI0000279
| ID=hsa-mir-196a-2
| offset=-22
}}

{{PMID Auto
|PMID=19293314
|Title=A Functional Genetic Variant in microRNA-196a2 Is Associated with Increased Susceptibility of Lung Cancer in Chinese.
}}

{{PMID Auto
|PMID=19514064
|Title=Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population
}}

{{PMID Auto
|PMID=19567675
|Title=microRNA miR-196a-2 and Breast Cancer: A Genetic and Epigenetic Association Study and Functional Analysis
|OA=1
}}
{{PMID Auto
|PMID=19834808
|Title=Association of MicroRNA-196a-2 Gene Polymorphism with Gastric Cancer Risk in a Chinese Population
}}
{{PMID Auto
|PMID=19847796
|Title=Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases
}}

{{PMID Auto
|PMID=20188135
|Title=Association of a variant in MIR196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection
}}

{{PMID Auto
|PMID=20229273
|Title=A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population
}}
{{PMID Auto
|PMID=20488170
|Title=Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy
}}
{{PMID Auto
|PMID=20501619
|Title=Mature miRNA sequence polymorphism in MIR196A2 is associated with risk and prognosis of head and neck cancer
|OA=1
}}
{{PMID Auto
|PMID=20549817
|Title=Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck
|OA=1
}}
{{PMID Auto
|PMID=20640596
|Title=The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis
}}
{{PMID Auto
|PMID=20722507
|Title=A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han
}}
{{PMID Auto
|PMID=20842445
|Title=Genetic variation in microRNA genes and prostate cancer risk in North Indian population
}}
{{PMID Auto
|PMID=20848167
|Title=Association Study of Common Genetic Variants in Pre-microRNAs in Patients with Ulcerative Colitis
}}
{{PMID Auto
|PMID=21073609
|Title=Association Between Common Genetic Variants in Pre-microRNAs and Gastric Cancer Risk in Japanese Population
}}
{{PMID Auto
|PMID=21080878
|Title=A variant in microRNA-196a2 is associated with susceptibility to hepatocellular carcinoma in Chinese patients with cirrhosis
}}
{{PMID Auto
|PMID=21241442
|Title=A variant in microRNA-196a2 is not associated with susceptibility to and progression of colorectal cancer in Chinese
}}

{{PMID Auto
|PMID=21565628
|Title=A Functional Variant in MicroRNA-196a2 Is Associated with Susceptibility of Colorectal Cancer in a Chinese Population
}}

{{PMID Auto
|PMID=21962133
|Title=Single Nucleotide Polymorphism in hsa-mir-196a-2 and Breast Cancer Risk: A Case Control Study
}}

{{PMID Auto
|PMID=21565178
|Title=Association between SNPs in pre-miRNA and risk of chronic obstructive pulmonary disease
}}

{{PMID Auto
|PMID=22291993
|Title=A Genetic Variant in miR-196a2 Increased Digestive System Cancer Risks: A Meta-Analysis of 15 Case-Control Studies
|OA=1
}}

{{PMID Auto
|PMID=22659075
|Title=Association of the miR-146aC>G, miR-196a2C>T, and miR-499A>G polymorphisms with moyamoya disease in the Korean population
}}

{{PMID|19047128|OA=1
}} Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.

{{PMID|19138993|OA=1
}} Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.

{{PMID|19232555|OA=1
}} Signatures of purifying and local positive selection in human miRNAs.

{{PMID|19290790|OA=1
}} MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine.

{{PMID|19423719|OA=1
}} Update in lung cancer 2008.

{{PMID|19458495|OA=1
}} Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes.

{{PMID|19617315|OA=1
}} SNPs in human miRNA genes affect biogenesis and function.

{{PMID|19881472}} Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis.

{{PMID|20428464|OA=1
}} MicroRNA polymorphisms: a giant leap towards personalized medicine.

{{PMID|20520619}} Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population.

{{PMID|21319225}} Common genetic polymorphisms in pre-microRNAs and risk of cervical squamous cell carcinoma.

{{PMID|21345130}} Investigative role of pre-microRNAs in bladder cancer patients: a case-control study in North India.

{{PMID|21625865}} A genetic variant in microRNA-196a2 is associated with increased cancer risk: a meta-analysis.

{{PMID|21663520}} Association between single-nucleotide polymorphisms in pre-miRNAs and the risk of asthma in a Chinese population.

{{PMID|21692953}} A functional polymorphism in pre-microRNA-196a-2 contributes to the susceptibility of hepatocellular carcinoma in a Turkish population: a case-control study.

{{PMID|21902575}} Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers.

{{PMID|22074121}} Associations of miRNA polymorphisms and female physiological characteristics with breast cancer risk in Chinese population.

{{PMID|22159951}} Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease.

{{PMID|22426473}} Lack of association of polymorphism in miRNA-196a2 with Parkinson's disease risk in a Chinese population.

{{PMID|22539802}} Impact of MiRSNPs on Survival and Progression in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation.

{{PMID Auto
|PMID=22719192
|Title=Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer
|OA=1
}}

{{PMID Auto
|PMID=23138850
|Title=miR-196a Overexpression and miR-196a2 Gene Polymorphism Are Prognostic Predictors of Oral Carcinomas
}}

{{PMID Auto
|PMID=23143626
|Title=Hsa-miR-196a2 Functional SNP is Associated With Severe Toxicity After Platinum-Based Chemotherapy of Advanced Nonsmall Cell Lung Cancer Patients in a Chinese Population
}}

{{PMID Auto
|PMID=22818121
|Title=The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer
}}

{{PMID Auto
|PMID=23228090
|Title=Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer
|OA=1
}}

{{PMID Auto
|PMID=23433405
|Title=A Single Nucleotide Polymorphism of miR-196a-2 and Vitiligo: An Association Study and Functional Analysis in a Han Chinese Population
}}

{{PMID Auto
|PMID=23470291
|Title=Association between Genetic Variants in Pre-MicroRNAs and Survival of Early-Stage NSCLC
}}

{{PMID Auto
|PMID=23516510
|Title=Associations of pri-miR-34b/c and pre-miR-196a2 Polymorphisms and Their Multiplicative Interactions with Hepatitis B Virus Mutations with Hepatocellular Carcinoma Risk
|OA=1
}}

{{PMID Auto
|PMID=23219900
|Title=Pre-microRNA variants predict HPV16-positive tumors and survival in patients with squamous cell carcinoma of the oropharynx
|OA=1
}}

{{PMID Auto
|PMID=23613771
|Title=Polymorphisms of microRNA Sequences or Binding Sites and Lung Cancer: A Meta-Analysis and Systematic Review
|OA=1
}}

{{PMID Auto
|PMID=23728616
|Title=Association between genetic variants in pre-miRNA and colorectal cancer risk in a Chinese population
}}

{{PMID Auto
|PMID=23928854
|Title=A functional variant of pre-miRNA-196a2 confers risk for Behcet's disease but not for Vogt-Koyanagi-Harada syndrome or AAU in ankylosing spondylitis
}}

{{PMID Auto
|PMID=23791656
|Title=Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: a systematic review and meta-analysis
}}

{{PMID Auto
|PMID=24254303
|Title=Two functional polymorphisms in microRNAs and lung cancer risk: a meta-analysis
}}

{{PMID Auto
|PMID=24291415
|Title=Hsa-miR-196a2 polymorphism increases the risk of acute lymphoblastic leukemia in Chinese children
}}

{{PMID Auto
|PMID=24320161
|Title=Hsa-miR-196a2 functional SNP is associated with the risk of ESCC in individuals under 60 years old
}}

{{PMID Auto
|PMID=24413317
|Title=MicroRNA sequence polymorphisms and the risk of different types of cancer
}}

{{PMID Auto
|PMID=24447667
|Title=A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression
}}

{{PMID Auto
|PMID=24568449
|Title=Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a, miR-149 and miR-499 with Colorectal Cancer Susceptibility
}}

{{PMID Auto
|PMID=23001871
|Title=Association of the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G polymorphisms with gastric cancer risk and survival in the Korean population.
}}

{{PMID Auto
|PMID=23160898
|Title=Quantitative assessment of the association between miR-196a2 rs11614913 polymorphism and gastrointestinal cancer risk.
}}

{{PMID Auto
|PMID=23423813
|Title=A functional polymorphism in MIR196A2 is associated with risk and prognosis of gastric cancer.
}}

{{PMID Auto
|PMID=23543085
|Title=Association study of genetic variants in miRNAs in patients with inflammatory bowel disease: preliminary results.
}}

{{PMID Auto
|PMID=23593385
|Title=Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=24039706
|Title=The associations of single nucleotide polymorphisms in miR-146a, miR-196a and miR-499 with breast cancer susceptibility
}}

{{PMID Auto
|PMID=24916311
|Title=MicroRNAs related polymorphisms and genetic susceptibility to esophageal squamous cell carcinoma
}}

{{PMID Auto
|PMID=24922658
|Title=Genetic Polymorphism of miR-196a as a Prognostic Biomarker for Early Breast Cancer
}}

{{PMID Auto
|PMID=24972764
|Title=Polymorphism in microRNA-196a2 contributes to the risk of cardiovascular disease in type 2 diabetes patients
}}

{{PMID Auto
|PMID=24978643
|Title=Genetic variants of MicroRNA-related genes in susceptibility and prognosis of end-stage renal disease and renal allograft outcome among north Indians
}}

{{PMID Auto
|PMID=25213291
|Title=Genetic Polymorphisms in miRNAs and Susceptibility to Colorectal Cancer
}}

{{PMID Auto
|PMID=24681820
|Title=Genetic variations in microRNAs and the risk and survival of renal cell cancer
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}