{{Rsnum
|rsid=11635424
|Gene=MAP2K5
|Chromosome=15
|position=67745240
|Orientation=plus
|GMAF=0.4545
|Gene_s=MAP2K5
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 4.4 | 48.7 | 46.9
| HCB | 37.2 | 52.6 | 10.2
| JPT | 43.4 | 44.2 | 12.4
| YRI | 69.4 | 27.2 | 3.4
| ASW | 40.4 | 50.9 | 8.8
| CHB | 37.2 | 52.6 | 10.2
| CHD | 37.6 | 45.9 | 16.5
| GIH | 27.7 | 40.6 | 31.7
| LWK | 52.7 | 42.7 | 4.5
| MEX | 39.7 | 50.0 | 10.3
| MKK | 39.1 | 42.3 | 18.6
| TSI | 14.7 | 40.2 | 45.1
| HapMapRevision=28
}}[[rs11635424]], a SNP located in a region of chromosome 15q, has been linked to a lower frequency of [[restless legs syndrome]], a common sleep disorder, with an overall odds ratio of 0.70 (CI: 0.59-0.82) for the (A) minor allele. {{PMID|17637780}}
{{ neighbor
| rsid = 12593813
| distance = 726
}}

{{PharmGKB
|RSID=rs11635424
|Name_s=
|Gene_s=MAP2K5
|Feature=
|Evidence=PubMed ID:17637780
|Annotation=In replicated GWAS case-control studies of Caucasian(European and French-Canadian) familial and sporadic RLS, the G allele of rs11635424 was significantly associated with Restless Legs Syndrome.
|Drugs=
|Drug Classes=
|Diseases=Restless Legs Syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA162355630
}}

{{PMID Auto
|PMID=19279021
|Title=Replication of restless legs syndrome loci in three European populations.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11635424
|overall_frequency_n=51
|overall_frequency_d=128
|overall_frequency=0.398438
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=40
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}