{{Rsnum
|rsid=11649743
|Gene=HNF1B
|Chromosome=17
|position=37714971
|Orientation=plus
|GMAF=0.2025
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=HNF1B
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 6.2 | 36.3 | 57.5
| HCB | 9.5 | 48.2 | 42.3
| JPT | 8.8 | 46.0 | 45.1
| YRI | 0.0 | 10.2 | 89.8
| ASW | 1.8 | 10.5 | 87.7
| CHB | 9.5 | 48.2 | 42.3
| CHD | 13.8 | 40.4 | 45.9
| GIH | 1.0 | 14.9 | 84.2
| LWK | 0.0 | 12.7 | 87.3
| MEX | 1.7 | 34.5 | 63.8
| MKK | 2.6 | 29.5 | 67.9
| TSI | 4.9 | 28.4 | 66.7
| HapMapRevision=28
}}

{{PMID|19998368|OA=1
}} [[rs11649743]] identified as one of three [[HNF1B]] gene SNPs associated with decreased risk for [[prostate cancer]] in two large prospective studies 

{{PMID|18758462|OA=1
}} [[prostate cancer]] [[rs4430796]] and [[rs11649743]] in multiple populations, with P = 1.7 x 10(-9)

{{omim
|desc=PROSTATE CANCER, HEREDITARY, 11; HPC11
|id=611955
|rsnum=11649743
}}

{{PharmGKB
|RSID=rs11649743
|Name_s=
|Gene_s=HNF1B
|Feature=
|Evidence=PubMed ID:18758462
|Annotation=In a fine-mapping study in the HNF1B gene at 17q12 this variant was associated with prostate cancer risk.
|Drugs=
|Drug Classes=
|Diseases=Prostatic Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162355654
}}

{{PMID Auto
|PMID=21576123
|Title=Large-scale fine mapping of the HNF1B locus and prostate cancer risk
|OA=1
}}

{{PMID Auto
|PMID=19117981
|Title=Sequence variants at 22q13 are associated with prostate cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19168595
|Title=Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=19318432
|Title=Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.
|OA=1
}}

{{PMID Auto
|PMID=19434657
|Title=Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
|OA=1
}}

{{PMID Auto
|PMID=19549807
|Title=Prostate cancer risk associated loci in African Americans.
|OA=1
}}

{{PMID Auto
|PMID=20039378
|Title=Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
|OA=1
}}

{{PMID Auto
|PMID=20569440
|Title=Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=21390317
|Title=Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11649743
|overall_frequency_n=12
|overall_frequency_d=128
|overall_frequency=0.09375
|n_genomes=10
|n_genomes_annotated=0
|n_haplomes=10
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23405784
|Title=[Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases]
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}