{{Rsnum
|rsid=11650354
|Gene=TBX21
|Chromosome=17
|position=47744726
|Orientation=plus
|GMAF=0.1244
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TBX21
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 66.4 | 31.0 | 2.7
| HCB | 86.1 | 13.1 | 0.7
| JPT | 94.7 | 5.3 | 0.0
| YRI | 83.0 | 16.3 | 0.7
| ASW | 77.2 | 22.8 | 0.0
| CHB | 86.1 | 13.1 | 0.7
| CHD | 90.8 | 8.3 | 0.9
| GIH | 67.3 | 30.7 | 2.0
| LWK | 81.8 | 16.4 | 1.8
| MEX | 74.1 | 25.9 | 0.0
| MKK | 82.1 | 16.7 | 1.3
| TSI | 65.7 | 23.5 | 10.8
| HapMapRevision=28
}}A large study of Caucasian children has identified this SNP in the [[TBX21]] gene (and one other, [[rs16947078]]) as defining a haplotype associated with increased risk for allergic [[asthma]]. {{PMID|17949803}}

The odds ratio associated with [[rs11650354]](T;T) homozygotes compared to [[rs11650354]](C;C) homozygotes for allergic [[asthma]] is reported to be 8.13 (CI: 2.5-26.9). Heterozygotes may be at slightly higher risk. {{PMID|17949803}}

{{PMID Auto
|PMID=19950257
|Title=Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: Evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines
|OA=1
}}

{{PMID|18504423|OA=1
}} Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response.

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}