{{Rsnum
|rsid=1165205
|Gene=SLC17A3
|Chromosome=6
|position=25870314
|Orientation=plus
|GMAF=0.2824
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=SLC17A3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 22.3 | 51.8 | 25.9
| HCB | 2.2 | 29.9 | 67.9
| JPT | 3.5 | 28.3 | 68.1
| YRI | 0.0 | 6.1 | 93.9
| ASW | 0.0 | 24.6 | 75.4
| CHB | 2.2 | 29.9 | 67.9
| CHD | 3.7 | 30.3 | 66.1
| GIH | 26.7 | 53.5 | 19.8
| LWK | 0.0 | 1.8 | 98.2
| MEX | 15.5 | 43.1 | 41.4
| MKK | 0.6 | 12.9 | 86.5
| TSI | 38.2 | 47.1 | 14.7
| HapMapRevision=28
}}[[rs1165205]] is a SNP in the [[SLC17A3]] gene on ch 6.

A large study totaling 7,699 participants in the Framingham cohort and 4,148 participants in the Rotterdam cohort was conducted, with genome-wide significant SNPs then replicated in 11,000+ Caucasian and ~4,000 African-American individuals who took part in the study of Atherosclerosis Risk in Communities (ARIC). This study calculated an odds ratio of 0.85 for [[rs1165205]], (CI: 0.77-0.94, p = 0.002). A genetic score comprised of this SNP plus 2 others may stratify risk for [[gout]]. {{PMID|18834626|OA=1
}}

See also: [http://blog.23andme.com/2008/10/01/snpwatch-three-new-associations-for-gout-strengthen-genetic-link/ 23andMe blog] [[gout]]
*[[rs2231142]](T) 1.7x 
*[[rs16890979]](C) 1.7x 
*[[rs1165205]](A) 1.2x

{{omim
|desc=URIC ACID CONCENTRATION, SERUM, QUANTITATIVE TRAIT LOCUS 3; UAQTL4
|id=612671
|rsnum=1165205
}}

{{PharmGKB
|RSID=rs1165205
|Name_s=
|Gene_s=SLC17A3
|Feature=
|Evidence=PubMed ID:18834626; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. (Initial Sample Size: 11,847 individuals; Replication Sample Size: 14,867 individuals); (Region: 6p22.2; Reported Gene: SLC17A3; Risk Allele: rs1165205-?) This variant is associated with Serum urate.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740886
}}

{{PharmGKB
|RSID=rs1165205
|Name_s=
|Gene_s=SLC17A3
|Feature=
|Evidence=PubMed ID:18834626; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. (Initial Sample Size: 11,847 individuals; Replication Sample Size: 14,867 individuals); (Region: 6p22.2; Reported Gene(s): SLC17A3; Risk Allele: rs1165205-?); (p-value= 3.99999999999999E-29).This variant is associated with Serum urate.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740845
}}

{{PMID Auto
|PMID=19503597
|Title=Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
|OA=1
}}

{{PMID Auto
|PMID=19890391
|Title=Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease.
|OA=1
}}

{{PMID Auto
|PMID=20053405
|Title=Sex and age interaction with genetic association of atherogenic uric acid concentrations.
|OA=1
}}

{{PMID Auto
|PMID=20470424
|Title=A three-stage approach for genome-wide association studies with family data for quantitative traits.
|OA=1
}}

{{PMID Auto
|PMID=21765209
|Title=Serum and cerebrospinal fluid uric acid levels in lewy body disorders: associations with disease occurrence and amyloid-beta pathway.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1165205
|overall_frequency_n=84
|overall_frequency_d=128
|overall_frequency=0.65625
|n_genomes=48
|n_genomes_annotated=0
|n_haplomes=76
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}