{{Rsnum
|rsid=11655505
|Gene=NBR2
|Chromosome=17
|position=43126360
|Orientation=plus
|GMAF=0.3274
|Gene_s=BRCA1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}Although [[BRCA1]] gene SNP [[rs11655505]](T) is mentioned in PharmGKB as having a protective association with risk for breast cancer, a more recent study of 2912 female breast cancer cases and 2783 unaffected female controls from four Caucasian breast cancer studies found no evidence for any association between rs11655505 and breast cancer risk.{{PMID|20413709}}

{{PharmGKB
|RSID=rs11655505
|Name_s=BRCA1: -2265C>T
|Gene_s=NBR2, BRCA1
|Feature=
|Evidence=PubMed ID:18782836
|Annotation=This variant is in the promoter region of BRCA1. T allele is associated with increased promoter activity compared with the A allele. The carriers of T allele had a reduced risk of breast cancer in chinese women. The associate is more prominent in women aged >=45 years, particularly those without a family history of breast cancer.
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms; Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162370344
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11655505
|overall_frequency_n=39
|overall_frequency_d=128
|overall_frequency=0.304688
|n_genomes=26
|n_genomes_annotated=0
|n_haplomes=30
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23263908
|Title=Association of BRCA1 promoter methylation with rs11655505 (c.2265C>T) variants and decreased gene expression in sporadic breast cancer.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}