{{Rsnum
|rsid=1169300
|Gene=HNF1A
|Chromosome=12
|position=120993422
|Orientation=plus
|GMAF=0.3315
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=HNF1A
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 7.1 | 45.1 | 47.8
| HCB | 19.5 | 54.9 | 25.6
| JPT | 34.5 | 54.0 | 11.5
| YRI | 1.4 | 12.9 | 85.7
| ASW | 0.0 | 28.1 | 71.9
| CHB | 19.5 | 54.9 | 25.6
| CHD | 21.5 | 47.7 | 30.8
| GIH | 19.8 | 44.6 | 35.6
| LWK | 2.7 | 29.1 | 68.2
| MEX | 14.0 | 38.6 | 47.4
| MKK | 1.9 | 42.6 | 55.5
| TSI | 10.8 | 44.1 | 45.1
| HapMapRevision=28
}}

[[rs1169300]] is a SNP that was originally associated with C-reactive protein levels, and given other findings that suggest C-reactive protein levels may be predictive of cancer risk, was thought to be linked to cancer risk.

A large study pooling data from 3 Finnish studies totaling over 18,000 individuals concluded that while this SNP is not likely to be causative (relative to cancer), it and one other CRP SNP ([[rs2464196]]) are associated with increased risk for [[lung cancer]]. The odds ratio for minor alleles of either SNP was about 1.5x and 2x for heterozygotes and homozygotes, respectively. One other CRP SNP ([[rs1892534]]) was associated with increased overall [[cancer]] risk.  CRP SNPs were not associated with colorectal, prostate or breast cancer risk.{{PMID|20727736}}

{{PMID Auto
|PMID=18439548
|Title=Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=18599530
|Title=Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients.
|OA=1
}}

{{PMID Auto
|PMID=19060910
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}