{{Rsnum
|rsid=1169310
|Gene=HNF1A
|Chromosome=12
|position=121001630
|Orientation=plus
|GMAF=0.3669
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=HNF1A
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 13.8 | 46.2 | 40.0
| HCB | 22.2 | 62.2 | 15.6
| JPT | 43.2 | 47.7 | 9.1
| YRI | 3.2 | 12.7 | 84.1
| ASW | 0.0 | 0.0 | 0.0
| CHB | 22.2 | 62.2 | 15.6
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs1169310
|PubMedID=18439552
|Condition=C-reactive protein
|Gene=HNF1A
|Risk Allele=A
|pValue=2.00E-008
|OR=0.13
|95CI=0.08-0.17) mg/l decrease in log(CRP) leve
|OA=1
}}

{{PharmGKB
|RSID=rs1169310
|Name_s=
|Gene_s=C12orf43, HNF1A
|Feature=
|Evidence=PubMed ID:18439552
|Annotation=In a candidate gene-based association analysis of 4333 European-descended, age 65 or older, subjects from the CHS study (Cardiovascular Health Study), this was one of the SNPs most strongly associated with plasma C-reactive protein levels. The minor allele is part of a haplotype of frequency 30% which was associated with lower levels of CRP.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases
|Curation Level=Curated
|PharmGKB Accession ID=PA162400659
}}

{{PharmGKB
|RSID=rs1169310
|Name_s=
|Gene_s=C12orf43, HNF1A
|Feature=
|Evidence=PubMed ID:18439552; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1 Alpha are Associated with C-Reactive Protein (Initial Sample Size: 909 individuals; Replication Sample Size: 5,106 individuals; Risk Allele: rs1169310-A). This variant is associated with C-reactive protein levels.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Metabolic Syndrome X; Myocardial Infarction; Stroke
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356795
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=21195701
|Title=Effect of obesity on the association between common variations in the HNF1A gene region and C-reactive protein level in Taiwanese.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1169310
|overall_frequency_n=41
|overall_frequency_d=128
|overall_frequency=0.320312
|n_genomes=27
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}