{{Rsnum
|rsid=1169313
|Gene=C12orf43
|Chromosome=12
|position=121004867
|Orientation=plus
|GMAF=0.3682
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=C12orf43
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 12.4 | 51.3 | 36.3
| HCB | 19.1 | 55.9 | 25.0
| JPT | 36.3 | 52.2 | 11.5
| YRI | 1.4 | 14.3 | 84.4
| ASW | 1.8 | 31.6 | 66.7
| CHB | 19.1 | 55.9 | 25.0
| CHD | 21.1 | 47.7 | 31.2
| GIH | 27.7 | 41.6 | 30.7
| LWK | 2.7 | 29.1 | 68.2
| MEX | 15.5 | 37.9 | 46.6
| MKK | 6.4 | 46.2 | 47.4
| TSI | 16.7 | 50.0 | 33.3
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=18940312
|Trait=Plasma levels of liver enzymes
|Title=Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
|RiskAllele=C
|Pval=2E-10
|OR=0.01
|ORtxt=[0.003-0.007] U/L decrease
|OA=1
}}

{{omim
|desc=GAMMA GLUTAMYLTRANSFERASE, PLASMA LEVEL OF, QUANTITATIVE TRAIT LOCUS
|id=612366
|rsnum=1169313
}}

{{PharmGKB
|RSID=rs1169313
|Name_s=
|Gene_s=C12orf43, HNF1A
|Feature=
|Evidence=PubMed ID:18940312; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (Initial Sample Size: 7,751 European white individuals; Replication Sample Size: 4,704 European white and Indian Asian individua); (Region: 12q24.2; Reported Gene(s): HNF1A, C12orf27, C12orf43; Risk Allele: rs1169313-C); (p-value= 0.0000000002).This variant is associated with Plasma levels of liver enzymes.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740804
}}

{{PMID Auto
|PMID=18439552
|Title=Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
|OA=1
}}

{{PMID Auto
|PMID=19198612
|Title=New susceptibility locus for coronary artery disease on chromosome 3q22.3.
|OA=1
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1169313
|overall_frequency_n=41
|overall_frequency_d=128
|overall_frequency=0.320312
|n_genomes=27
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}