{{Rsnum
|rsid=1172822
|Gene=BRSK1
|Chromosome=19
|position=55308477
|Orientation=plus
|GMAF=0.2691
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=BRSK1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 41.6 | 46.0 | 12.4
| HCB | 84.7 | 13.1 | 2.2
| JPT | 88.5 | 11.5 | 0.0
| YRI | 55.8 | 38.8 | 5.4
| ASW | 54.4 | 36.8 | 8.8
| CHB | 84.7 | 13.1 | 2.2
| CHD | 86.1 | 13.0 | 0.9
| GIH | 23.8 | 48.5 | 27.7
| LWK | 60.0 | 36.4 | 3.6
| MEX | 41.4 | 55.2 | 3.4
| MKK | 53.8 | 42.9 | 3.2
| TSI | 32.4 | 44.1 | 23.5
| HapMapRevision=28
}}
[http://blog.23andme.com/2009/05/18/snpwatch-researchers-link-common-genetic-variations-to-those-changes-a-womans-body-goes-through/ 23andMe blog] [[rs1172822]](T) 	[[Menopause]] about 25 weeks earlier

{{PMID Auto GWAS
|PMID=19448619
|Trait=Menopause
|Title=Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
|RiskAllele=T
|Pval=6E-11
|OR=0.39
|ORtxt=[0.27-0.51] years younger
|OA=1
}}
{{PMID Auto GWAS
|PMID=19448621
|Trait=Menarche and menopause (age at onset)
|Title=Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
|RiskAllele=T
|Pval=2E-19
|OR=0.49
|ORtxt=[0.38-0.60] years younger
|OA=1
}}

{{omim
|id=612884
|rsnum=1172822
}}

{{PMID Auto
|PMID=19664201
|Title=Genetic and genomic insights into age at natural menopause.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1172822
|overall_frequency_n=30
|overall_frequency_d=128
|overall_frequency=0.234375
|n_genomes=21
|n_genomes_annotated=0
|n_haplomes=26
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23508249
|Title=Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study
}}

{{PMID Auto
|PMID=23536822
|Title=Evaluating GWAS-Identified SNPs for Age at Natural Menopause among Chinese Women
|OA=1
}}

{{PMID Auto
|PMID=23592221
|Title=Shared genetic factors for age at natural menopause in Iranian and European women
}}

{{PMID Auto
|PMID=23360674
|Title=Genetic variation may modify ovarian reserve in female childhood cancer survivors.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}