{{Rsnum
|rsid=11754661
|Gene=MTHFD1L
|Chromosome=6
|position=150885942
|Orientation=plus
|GMAF=0.03811
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=MTHFD1L
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 13.3 | 86.7
| HCB | 0.0 | 8.2 | 91.8
| JPT | 0.0 | 7.1 | 92.9
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 8.2 | 91.8
| CHD | 0.0 | 7.5 | 92.5
| GIH | 0.0 | 6.9 | 93.1
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 3.4 | 96.6
| MKK | 0.0 | 1.3 | 98.7
| TSI | 1.0 | 7.9 | 91.1
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs11754661
|Name_s=
|Gene_s=MTHFD1L
|Feature=
|Evidence=PubMed ID:19118814
|Annotation=This variant is significantly associated with late-onset Alzheimer disease (LOAD) in a GWAS study with 492 LOAD cases and 498 cognitive controls using Illumina's HumanHap550 beadchip.
|Drugs=
|Drug Classes=
|Diseases=Alzheimer Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA162363820
}}

This SNP in the [[MTHFD1L]] gene is associated with late-onset [[Alzheimer's disease]], according to an article in [http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001130 PLoS Genetics].
{{PMID Auto
|PMID=20885792
|Title=Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities
|OA=1
}}

{{PMID Auto
|PMID=21383495
|Title=The MTHFD1L Gene rs11754661 Marker is Not Associated with Alzheimer's Disease in a Sample of the Spanish Population
}}

{{PMID Auto
|PMID=21741665
|Title=The MTHFD1L gene rs11754661 marker is associated with susceptibility to Alzheimer's disease in the Chinese Han population
}}

{{PMID Auto
|PMID=22330827
|Title=Replication of the MTHFD1L gene association with late-onset Alzheimer's disease in a Northern Han Chinese population.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs11754661
|overall_frequency_n=8
|overall_frequency_d=128
|overall_frequency=0.0625
|n_genomes=5
|n_genomes_annotated=0
|n_haplomes=5
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}